@prefix vh8: <http://data.loterre.fr/ark:/67375/VH8> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .

vh8:-XRQCWM3P-Q
  skos:prefLabel "anomalie de la membrane érythrocytaire"@fr, "erythrocytic membrane disease"@en ;
  a skos:Concept ;
  skos:narrower vh8:-W7L2XVNV-W .

vh8: a skos:ConceptScheme .
vh8:-W7L2XVNV-W
  skos:broader vh8:-XRQCWM3P-Q ;
  skos:exactMatch <https://fr.wikipedia.org/wiki/H%C3%A9moglobinurie_paroxystique_nocturne>, <https://en.wikipedia.org/wiki/Paroxysmal_nocturnal_hemoglobinuria> ;
  skos:altLabel "hémoglobinurie paroxystique nocturne"@fr ;
  a skos:Concept ;
  skos:prefLabel "anémie hémolytique de Marchiafava-Micheli"@fr, "nocturnal paroxystic anemia"@en ;
  skos:definition "Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, life-threatening disease of the blood characterized by destruction of red blood cells by the complement system, a part of the body's innate immune system. This destructive process occurs due to the presence of defective surface protein DAF on the red blood cell, which normally functions to inhibit such immune reactions. Since the complement cascade attacks the red blood cells within the blood vessels of the circulatory system, the red blood cell destruction (hemolysis) is considered an intravascular hemolytic anemia. Other key features of the disease, such as the high incidence of blood clot formation, are incompletely understood. (Wikipedia)"@en, "L'hémoglobinurie paroxystique nocturne (HPN) , aussi appelée maladie de « Marchiafava et Michelli » est une cause rare d'anémie.  (Wikipédia)"@fr ;
  skos:inScheme vh8: .