@prefix qx8: . @prefix skos: . qx8: a skos:ConceptScheme . qx8:-GM4FXS76-7 skos:prefLabel "biological object"@en, "objet biologique"@fr ; a skos:Concept ; skos:narrower qx8:-X2QVP92C-P . qx8:-X2QVP92C-P a skos:Concept ; skos:definition "Nucleotides are organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth. Nucleotides are obtained in the diet and are also synthesized from common nutrients by the liver. Nucleotides are composed of three subunit molecules: a nucleobase, a five-carbon sugar (ribose or deoxyribose), and a phosphate group consisting of one to three phosphates. The four nucleobases in DNA are guanine, adenine, cytosine and thymine; in RNA, uracil is used in place of thymine. Nucleotides also play a central role in metabolism at a fundamental, cellular level. They provide chemical energy—in the form of the nucleoside triphosphates, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP) and uridine triphosphate (UTP)—throughout the cell for the many cellular functions that demand energy, including: amino acid, protein and cell membrane synthesis, moving the cell and cell parts (both internally and intercellularly), cell division, etc. In addition, nucleotides participate in cell signaling (cyclic guanosine monophosphate or cGMP and cyclic adenosine monophosphate or cAMP), and are incorporated into important cofactors of enzymatic reactions (e.g. coenzyme A, FAD, FMN, NAD, and NADP+). (Adapted from: https://en.wikipedia.org/wiki/Nucleotide)"@en, "Un nucléotide est une molécule organique qui est composée d'une base nucléique (ou base azotée), d'un ose à cinq atomes de carbone, dit pentose, dont l'association forme un nucléoside, et enfin de un à trois groupes phosphate. L'adénosine triphosphate, dite ATP, est un nucléotide dont l'hydrolyse sous forme d'ADP et de phosphate libère une quantité d'énergie utilisée dans l'activité de la cellule animale ; plus généralement, sous la forme de dNTP (ATP, GTP, CTP, UTP), les nucléotides jouent un rôle central dans le métabolisme. Les nucléotides participent également à la signalisation cellulaire. Certains sont des cofacteurs ou coenzymes de réactions biochimiques. Les nucléotides constituent l'élément de base d'un acide nucléique tel que l'ADN ou l'ARN. (Adapté de : https://fr.wikipedia.org/wiki/Nucl%C3%A9otide)"@fr ; skos:broader qx8:-GM4FXS76-7 ; skos:exactMatch , ; skos:prefLabel "nucléotide"@fr, "nucleotide"@en ; skos:inScheme qx8: ; skos:related qx8:-BDF963TD-8 . qx8:-BDF963TD-8 skos:prefLabel "DNA"@en, "ADN"@fr ; a skos:Concept ; skos:related qx8:-X2QVP92C-P .