@prefix p66: <http://data.loterre.fr/ark:/67375/P66> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix inist: <http://www.inist.fr/Ontology#> .
@prefix isothes: <http://purl.org/iso25964/skos-thes#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix uneskos: <http://purl.org/umu/uneskos#> .

p66:-G4CV58RJ-C
  skos:prefLabel "engramme"@fr, "engram"@en ;
  a skos:Concept ;
  inist:hasStudyMethod p66:-CT8NQP8K-R ;
  skos:related p66:-CT8NQP8K-R .

p66:-F1HG1ZMR-D
  skos:prefLabel "silent engram"@en, "engramme silencieux"@fr ;
  a skos:Concept ;
  skos:related p66:-CT8NQP8K-R .

p66:-Génétique
  skos:prefLabel "Génétique"@fr, "Genetics"@en ;
  a isothes:ConceptGroup ;
  skos:member p66:-CT8NQP8K-R .

p66:-Neurophysiologie
  skos:prefLabel "Neurophysiologie"@fr, "Neurophysiology"@en ;
  a isothes:ConceptGroup ;
  skos:member p66:-CT8NQP8K-R .

p66: a skos:ConceptScheme .
p66:-FBXSVC7N-L
  skos:prefLabel "méthode neurophysiologique"@fr, "neurophysiological method"@en ;
  a skos:Concept ;
  skos:narrower p66:-CT8NQP8K-R .

p66:-CT8NQP8K-R
  skos:prefLabel "optogenetics"@en, "optogénétique"@fr ;
  skos:related p66:-G4T4V894-V, p66:-F1HG1ZMR-D, p66:-G4CV58RJ-C ;
  skos:definition "\"Optogenetic technology combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within intact, living neural circuits.\" (Deisseroth et al., 2006, p. 10380)."@en, "Méthode consistant à insérer, dans des neurones sélectivement ciblés, des gènes codant pour une protéine photosensible, de la classe des opsines, provoquant alors soit une dépolarisation (lumière bleue pour les channelrhodopsines R2ou chR2), soit l'hyperpolarisation (lumière jaune pour les halorhodopsines) des neurones. Dans le premier cas, la lumière va activer les neurones, dans le second cas, elle va les inhiber."@fr ;
  dc:created "2018-03-15"^^xsd:date ;
  a skos:Concept ;
  dc:creator "Frank Arnould" ;
  skos:exactMatch jvr:-NKGJNM4K-X, <https://fr.wikipedia.org/wiki/Optogénétique>, <https://en.wikipedia.org/wiki/Optogenetics>, <https://www.wikidata.org/wiki/Q781492> ;
  skos:altLabel "optogenetic stimulation"@en, "stimulation optogénétique"@fr ;
  uneskos:memberOf p66:-Neurophysiologie, p66:-Génétique, p66:-Homme, p66:-Animal ;
  skos:broader p66:-FBXSVC7N-L ;
  skos:inScheme p66: ;
  dc:bibliographicCitation """<span class ="replaced2">	•	 Deisseroth, K., Feng, G., Majewska, A. K., Miesenböck, G., Ting, A., & Schnitzer, M. J. (2006). Next-generation optical technologies for illuminating genetically targeted brain circuits. Journal of Neuroscience, 26(41), 10380–10386.  <a href="https://doi.org/10.1523/JNEUROSCI.3863-06.2006">https://doi.org/10.1523/JNEUROSCI.3863-06.2006</a></span> <span class="reified-property-value xl-pref-label tooltip-html"><p><img src="resource/pics/infoBlue.png"/>	</p><div class="reified-tooltip tooltip-html-content"><p><span class="tooltip-prop">• Type de document</span> : <span class="versal">revue de la littérature</span></p> <p><span class="tooltip-prop">• Accès</span> : <span class="versal">ouvert</span></p>"""@fr, """<span class ="replaced2">	•	 ​Mudiayi, D., Wong, S., & Gruber, A. (2015). Optogenetics. In J. D. Wright (Ed.), International Encyclopedia of the Social & Behavioral Sciences (Second Edition) (p. 268–273). Oxford: Elsevier.  <a href="https://doi.org/10.1016/B978-0-08-097086-8.55060-0">https://doi.org/10.1016/B978-0-08-097086-8.55060-0</a></span> <span class="reified-property-value xl-pref-label tooltip-html"><p><img src="resource/pics/infoBlue.png"/>	</p><div class="reified-tooltip tooltip-html-content"><p><span class="tooltip-prop">• Document type</span>: <span class="versal">literature review</span></p> <p><span class="tooltip-prop">• Access</span>: <span class="versal">closed</span></p>"""@en, """<span class ="replaced2">	•	 ​Mudiayi, D., Wong, S., & Gruber, A. (2015). Optogenetics. In J. D. Wright (Ed.), International Encyclopedia of the Social & Behavioral Sciences (Second Edition) (p. 268–273). Oxford: Elsevier.  <a href="https://doi.org/10.1016/B978-0-08-097086-8.55060-0">https://doi.org/10.1016/B978-0-08-097086-8.55060-0</a></span> <span class="reified-property-value xl-pref-label tooltip-html"><p><img src="resource/pics/infoBlue.png"/>	</p><div class="reified-tooltip tooltip-html-content"><p><span class="tooltip-prop">• Type de document</span> : <span class="versal">revue de la littérature</span></p> <p><span class="tooltip-prop">• Accès</span> : <span class="versal">fermé</span></p>"""@fr, """<span class ="replaced2">	•	 Deisseroth, K., Feng, G., Majewska, A. K., Miesenböck, G., Ting, A., & Schnitzer, M. J. (2006). Next-generation optical technologies for illuminating genetically targeted brain circuits. Journal of Neuroscience, 26(41), 10380–10386.  <a href="https://doi.org/10.1523/JNEUROSCI.3863-06.2006">https://doi.org/10.1523/JNEUROSCI.3863-06.2006</a></span> <span class="reified-property-value xl-pref-label tooltip-html"><p><img src="resource/pics/infoBlue.png"/>	</p><div class="reified-tooltip tooltip-html-content"><p><span class="tooltip-prop">• Document type</span>: <span class="versal">literature review</span></p> <p><span class="tooltip-prop">• Access</span>: <span class="versal">open</span></p>"""@en ;
  dc:modified "2023-09-04"^^xsd:date ;
  inist:isStudyMethodOf p66:-G4CV58RJ-C ;
  skos:hiddenLabel "optogenetically"@en .

p66:-G4T4V894-V
  skos:prefLabel "cellule d'engramme"@fr, "engram cell"@en ;
  a skos:Concept ;
  skos:related p66:-CT8NQP8K-R .

p66:-Animal
  skos:prefLabel "Animal non humain"@fr, "Nonhuman animal"@en ;
  a isothes:ConceptGroup ;
  skos:member p66:-CT8NQP8K-R .

p66:-Homme
  skos:prefLabel "Human"@en, "Homme"@fr ;
  a isothes:ConceptGroup ;
  skos:member p66:-CT8NQP8K-R .