@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-ZTRXT0MG-0
  mesh:allowableQualifier jvr:-T9HQD7ST-J, jvr:-NHL3D2X0-S, jvr:-R3QWLHRG-V, jvr:-W6SQV79N-S, jvr:-Z9TSGBXH-4, jvr:-FWD2BGQ0-9, jvr:-D0F21513-5, jvr:-NFTHND7Q-8, jvr:-S0CS1X5R-5, jvr:-M63HSDM7-1, jvr:-TJHVZCRZ-0, jvr:-BT300B3G-Q, jvr:-SBNWSM1T-R, jvr:-L6C0XPHT-4, jvr:-CJXMKG5Q-F, jvr:-WZF2ZR3L-B, jvr:-HQRFT0C6-B, jvr:-CB30NGKB-3, jvr:-WK5F724J-1, jvr:-NB0XHT3S-N, jvr:-Q3979798-W, jvr:-N2WP45CN-V, jvr:-T2TS0S41-N, jvr:-THHNVC7V-3, jvr:-G30ZJ446-J, jvr:-G7KXQWSR-5, jvr:-NKM836P1-M, jvr:-H7K65Q8S-Z, jvr:-XV06LPML-W ;
  a mesh:Descriptor, skos:Concept ;
  dc:modified "2021-06-28"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000074923> ;
  skos:hiddenLabel "EC 3.4.21.108"@fr, "EC 3.4.21.108"@en ;
  skos:altLabel "Sérine peptidase A2 requise à température élevée"@fr, "HtrA2 Protease"@en, "Sérine protéase A2 requise à haute température"@fr, "Serine Protease HTRA2"@en, "Sérine protéase A2 requise à température élevée"@fr, "Serine Protease Omi"@en, "Sérine protéinase A2 requise à haute température"@fr, "HtrA Serine Peptidase 2"@en, "Sérine peptidase A2 requise à haute température"@fr, "Omi Serine Protease"@en, "Protéase HTRA2"@fr, "Serine protease HTRA2"@fr, "Sérine protéase HTRA2"@fr, "Sérine peptidase HtrA2"@fr, "Sérine protéase Omi"@fr ;
  skos:definition "A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE."@en ;
  mesh:registryNumber "EC 3.4.21.108" ;
  skos:related jvr:-STXPF8Q5-9 ;
  skos:prefLabel "High-temperature requirement A serine peptidase 2"@fr, "High-Temperature Requirement A Serine Peptidase 2"@en ;
  skos:broader jvr:-VZSXSG8R-Q, jvr:-G373PN6Q-J, jvr:-DLFK2M0S-P, jvr:-XRG3BMJZ-6 ;
  dc:established "2018-01-01"^^xsd:date ;
  dc:created "2017-07-11"^^xsd:date ;
  skos:inScheme jvr: .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-VZSXSG8R-Q
  skos:prefLabel "Serine endopeptidases"@fr, "Serine Endopeptidases"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-ZTRXT0MG-0 .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-STXPF8Q5-9
  skos:prefLabel "Domaines PDZ"@fr, "PDZ Domains"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-ZTRXT0MG-0 .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G373PN6Q-J
  skos:prefLabel "Protéines régulatrices de l'apoptose"@fr, "Apoptosis Regulatory Proteins"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-ZTRXT0MG-0 .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XRG3BMJZ-6
  skos:prefLabel "Parkinson Disease Associated Proteins"@en, "Protéines associées à la maladie de Parkinson"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-ZTRXT0MG-0 .

jvr:-DLFK2M0S-P
  skos:prefLabel "Protéines mitochondriales"@fr, "Mitochondrial Proteins"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-ZTRXT0MG-0 .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .