@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-T9F1N707-G skos:prefLabel "Group III Histone Deacetylases"@fr, "Group III Histone Deacetylases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-ZN52ZLS2-M . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-RZ7ZF59C-G skos:prefLabel "Intracellular Signaling Peptides and Proteins"@en, "Protéines et peptides de signalisation intracellulaire"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-ZN52ZLS2-M . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-RSCZK066-5 skos:prefLabel "Silent Information Regulator Proteins, Saccharomyces cerevisiae"@en, "Protéines SIR de Saccharomyces cerevisiae"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-ZN52ZLS2-M . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-J72RJJQG-0 skos:prefLabel "ADP Ribose Transferases"@en, "ADP ribose transferases"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-ZN52ZLS2-M . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XQZ2BQB8-3 skos:prefLabel "Sirtuine-3"@fr, "Sirtuin 3"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-ZN52ZLS2-M . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-ZQ2HL08G-7 skos:prefLabel "Sirtuine-2"@fr, "Sirtuin 2"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-ZN52ZLS2-M . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R4SCXMG7-H skos:prefLabel "Sirtuin 1"@en, "Sirtuine-1"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-ZN52ZLS2-M . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-ZN52ZLS2-M skos:altLabel "SIRTs"@en, "SIRT"@fr, "SIRT"@en, "Sir2-like Proteins"@en, "Silent Mating Type Information Regulator 2-like Proteins"@en, "Protéines Sir2-like"@fr, "Sirtuin"@en ; mesh:allowableQualifier jvr:-Q3979798-W, jvr:-G7KXQWSR-5, jvr:-T2TS0S41-N, jvr:-H7K65Q8S-Z, jvr:-FWD2BGQ0-9, jvr:-L6C0XPHT-4, jvr:-XV06LPML-W, jvr:-NHL3D2X0-S, jvr:-N2WP45CN-V, jvr:-NB0XHT3S-N, jvr:-Z9TSGBXH-4, jvr:-NKM836P1-M, jvr:-R3QWLHRG-V, jvr:-CB30NGKB-3, jvr:-G30ZJ446-J, jvr:-WZF2ZR3L-B, jvr:-D0F21513-5, jvr:-CJXMKG5Q-F, jvr:-W6SQV79N-S, jvr:-M63HSDM7-1, jvr:-WK5F724J-1, jvr:-NFTHND7Q-8, jvr:-THHNVC7V-3, jvr:-S0CS1X5R-5, jvr:-T9HQD7ST-J, jvr:-TJHVZCRZ-0, jvr:-HQRFT0C6-B, jvr:-BT300B3G-Q, jvr:-SBNWSM1T-R ; skos:narrower jvr:-ZQ2HL08G-7, jvr:-R4SCXMG7-H, jvr:-XQZ2BQB8-3 ; skos:prefLabel "Sirtuins"@en, "Sirtuines"@fr ; dc:modified "2020-05-27"^^xsd:date ; skos:broader jvr:-T9F1N707-G, jvr:-RZ7ZF59C-G, jvr:-J72RJJQG-0 ; dc:established "2003-01-01"^^xsd:date ; skos:hiddenLabel "EC 3.5.1.-"@en, "EC 3.5.1.-"@fr ; a skos:Concept, mesh:Descriptor ; skos:inScheme jvr: ; owl:sameAs ; mesh:registryNumber "EC 3.5.1.-" ; dc:created "2002-07-03"^^xsd:date ; skos:definition "A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities."@en ; skos:related jvr:-RSCZK066-5 . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .