@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S25VW0NW-8
  skos:prefLabel "Cyclin-Dependent Kinases"@en, "Kinases cyclines-dépendantes"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-Z2WMH7RD-S .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z2WMH7RD-S
  skos:prefLabel "Cyclin-Dependent Kinase 4"@en, "Kinase-4 cycline-dépendante"@fr ;
  mesh:allowableQualifier jvr:-WZF2ZR3L-B, jvr:-T9HQD7ST-J, jvr:-SBNWSM1T-R, jvr:-THHNVC7V-3, jvr:-XV06LPML-W, jvr:-L6C0XPHT-4, jvr:-NB0XHT3S-N, jvr:-D0F21513-5, jvr:-Z9TSGBXH-4, jvr:-H7K65Q8S-Z, jvr:-FWD2BGQ0-9, jvr:-T2TS0S41-N, jvr:-CJXMKG5Q-F, jvr:-NFTHND7Q-8, jvr:-HQRFT0C6-B, jvr:-CB30NGKB-3, jvr:-G7KXQWSR-5, jvr:-WK5F724J-1, jvr:-TJHVZCRZ-0, jvr:-NHL3D2X0-S, jvr:-BT300B3G-Q, jvr:-R3QWLHRG-V, jvr:-M63HSDM7-1, jvr:-N2WP45CN-V, jvr:-W6SQV79N-S, jvr:-Q3979798-W, jvr:-NKM836P1-M, jvr:-G30ZJ446-J, jvr:-S0CS1X5R-5 ;
  skos:altLabel "p34PSK-J3 Kinase"@en, "Kinase Cdk4 cycline-dépendante"@fr, "Protéine Cdk4"@fr, "Kinase cycline-dépendante de type 4"@fr, "Kinase-4 dépendante de cycline"@fr, "Kinase CDK4 dépendante de la cycline D"@fr, "Protéine-kinase-4 de la division cellulaire"@fr, "Cdk4 Cyclin-Dependent Kinase"@en, "Cdk4 Protein"@en, "Cell Division Protein Kinase 4"@en, "Kinase PSK-J3"@fr, "Kinase p34(PSK-J3)"@fr, "Protéine-kinase Cdk4"@fr, "Cdk4 Protein Kinase"@en, "Cyclin D-Dependent Kinase CDK4"@en, "PSK-J3 Kinase"@en ;
  mesh:registryNumber "EC 2.7.11.22" ;
  skos:broader jvr:-S25VW0NW-8 ;
  skos:hiddenLabel "EC 2.7.11.22"@fr, "EC 2.7.11.22"@en ;
  dc:modified "2021-05-21"^^xsd:date ;
  skos:inScheme jvr: ;
  a mesh:Descriptor, skos:Concept ;
  dc:created "2005-06-30"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D051358> ;
  skos:definition "Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16."@en ;
  dc:established "2006-01-01"^^xsd:date .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .