@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z0FST6G8-7
  skos:altLabel "CTLA-4 Protein"@en, "CD152"@fr, "Antigens, CD152"@en, "CD152 Antigen"@en, "Antigène CD152"@fr, "Antigène-4 associé au lymphocyte T cytotoxique"@fr, "Antigène-4 des lymphocytes T cytotoxiques"@fr, "Antigène-4 du lymphocyte T cytotoxique"@fr, "Cytotoxic T-Lymphocyte-Associated Antigen 4"@en, "CTLA-4"@fr, "Cytotoxic T-Lymphocyte Antigen 4"@en ;
  mesh:allowableQualifier jvr:-NHL3D2X0-S, jvr:-N2WP45CN-V, jvr:-Z9TSGBXH-4, jvr:-H7K65Q8S-Z, jvr:-G7KXQWSR-5, jvr:-SBNWSM1T-R, jvr:-M63HSDM7-1, jvr:-HQRFT0C6-B, jvr:-T2TS0S41-N, jvr:-Q3979798-W, jvr:-CJXMKG5Q-F, jvr:-S0CS1X5R-5, jvr:-W6SQV79N-S, jvr:-FWD2BGQ0-9, jvr:-R0ZCQ8X6-J, jvr:-L6C0XPHT-4, jvr:-TJHVZCRZ-0, jvr:-D0F21513-5, jvr:-WZF2ZR3L-B ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-LZZDT8GC-0, jvr:-VJGPQTB2-N, jvr:-TRQPC457-1 ;
  skos:inScheme jvr: ;
  skos:prefLabel "Antigène CTLA-4"@fr, "CTLA-4 Antigen"@en ;
  dc:created "2011-06-24"^^xsd:date ;
  skos:definition "An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE."@en ;
  dc:modified "2020-03-27"^^xsd:date ;
  skos:related jvr:-C2M2BDW0-1, jvr:-V4LF9LPH-N ;
  dc:established "2012-01-01"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D060908> .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-TRQPC457-1
  skos:prefLabel "Antigens, Differentiation, T-Lymphocyte"@en, "Antigènes de différenciation des lymphocytes T"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-Z0FST6G8-7 .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-VJGPQTB2-N
  skos:prefLabel "Costimulatory and Inhibitory T-Cell Receptors"@en, "Récepteurs costimulateurs et inhibiteurs des cellules T"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-Z0FST6G8-7 .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-LZZDT8GC-0
  skos:prefLabel "Immune Checkpoint Proteins"@en, "Protéines de points de contrôle immunitaires"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-Z0FST6G8-7 .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-C2M2BDW0-1
  skos:prefLabel "Abatacept"@fr, "Abatacept"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-Z0FST6G8-7 .

jvr:-V4LF9LPH-N
  skos:prefLabel "Ipilimumab"@fr, "Ipilimumab"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-Z0FST6G8-7 .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .