@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-VM502QRN-2
  skos:prefLabel "Gene Rearrangement, B-Lymphocyte, Heavy Chain"@en, "Réarrangement des gènes des chaines lourdes des lymphocytes B"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-XKXHNXDL-D .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-XKXHNXDL-D
  skos:altLabel "Commutation de classe des Ig"@fr, "Class Switching"@en, "Isotype Switching"@en, "Commutation isotypique"@fr, "Commutation de classe"@fr, "Commutation isotypique des Ig"@fr, "Switch isotypique"@fr, "Ig Class Switching"@en, "Commutation isotypique des immunoglobulines"@fr, "Commutation d'isotype"@fr ;
  dc:created "1993-06-17"^^xsd:date ;
  mesh:allowableQualifier jvr:-WZF2ZR3L-B, jvr:-PPKJKFKK-V, jvr:-Z9TSGBXH-4, jvr:-N2WP45CN-V, jvr:-H7K65Q8S-Z, jvr:-S0CS1X5R-5 ;
  a skos:Concept, mesh:Descriptor ;
  skos:inScheme jvr: ;
  skos:related jvr:-QCGRCZTL-6 ;
  skos:prefLabel "Immunoglobulin Class Switching"@en, "Commutation de classe des immunoglobulines"@fr ;
  skos:broader jvr:-VM502QRN-2 ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D017578> ;
  skos:definition "Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing."@en ;
  dc:established "1994-01-01"^^xsd:date ;
  dc:modified "2019-07-05"^^xsd:date .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-PPKJKFKK-V
  skos:prefLabel "ethics (Qualifier)"@en, "éthique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-QCGRCZTL-6
  skos:prefLabel "Immunoglobulin Switch Region"@en, "Région switch des immunoglobulines"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-XKXHNXDL-D .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .