@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-ZQS2168K-V
  skos:prefLabel "Inhibiteurs des canaux potassiques"@fr, "Potassium Channel Blockers"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZ0V0ND5-F
  skos:prefLabel "Agents neuromusculaires"@fr, "Neuromuscular Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-XGSS6DP5-3
  skos:altLabel "RU4S6E2G0J"@fr, "RU4S6E2G0J"@en, "3,4-Pyridinediamine"@fr, "3,4-Pyridinediamine"@en, "8HF8FIN815"@fr, "8HF8FIN815"@en, "3,4-Diaminopyridine"@en, "54-96-6 (Amifampridine)"@en, "54-96-6 (Amifampridine)"@fr ;
  a skos:Concept, mesh:Descriptor ;
  mesh:allowableQualifier jvr:-W6SQV79N-S, jvr:-T9HQD7ST-J, jvr:-R0ZCQ8X6-J, jvr:-CB30NGKB-3, jvr:-XV06LPML-W, jvr:-BT300B3G-Q, jvr:-M63HSDM7-1, jvr:-NKM836P1-M, jvr:-NHL3D2X0-S, jvr:-S0CS1X5R-5, jvr:-WK5F724J-1, jvr:-THHNVC7V-3, jvr:-FWD2BGQ0-9, jvr:-SBNWSM1T-R, jvr:-G30ZJ446-J, jvr:-R3QWLHRG-V, jvr:-NB0XHT3S-N, jvr:-H7K65Q8S-Z, jvr:-TJHVZCRZ-0, jvr:-L6C0XPHT-4, jvr:-D0F21513-5, jvr:-HQRFT0C6-B, jvr:-Q3979798-W, jvr:-NFTHND7Q-8, jvr:-G4R176S9-J ;
  mesh:pharmacologicalAction jvr:-WZ0V0ND5-F, jvr:-ZQS2168K-V ;
  dc:modified "2019-07-05"^^xsd:date ;
  skos:definition "4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES."@en ;
  skos:prefLabel "Amifampridine"@en, "Amifampridine"@fr ;
  skos:hiddenLabel "Phosphate d'amifampridine"@fr, "Amifampridine Phosphate"@en, "Ruzurgi"@en, "Firdapse"@en ;
  dc:established "2019-01-01"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000077770> ;
  skos:broader jvr:-LQSB4GJC-X ;
  skos:inScheme jvr: ;
  dc:created "2018-07-09"^^xsd:date .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-LQSB4GJC-X
  skos:prefLabel "4-Aminopyridine"@en, "4-Amino-pyridine"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-XGSS6DP5-3 .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .