@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-XDQ2DK5G-H skos:hiddenLabel "Sous-unité gamma des PDE de type 6"@fr, "beta Subunit, PDE6"@en, "Sous-unité alpha de PDE6"@fr, "gamma Subunit, cGMP Phosphodiesterase"@en, "delta Subunit, PDE6"@en, "Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit"@en, "Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit"@fr, "PDE6, alpha Subunit"@en, "Sous-unité bêta des PDE de type 6"@fr, "Sous-unité alpha des phosphodiestérases des nucléotides cycliques de type VI"@fr, "Sous-unité delta des phosphodiestérases des nucléotides cycliques de type 6"@fr, "Sous-unité bêta de la GMPc phosphodiestérase rétinienne"@fr, "Sous-unité alpha de la phosphodiestérase rétinienne"@fr, "Sous-unité gamma des phosphodiestérases des nucléotides cycliques de type 6"@fr, "Sous-unité alpha des PDE de type 6"@fr, "alpha Subunit, PDE6"@en, "Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit"@en, "Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit"@fr, "EC 3.1.4.17"@fr, "EC 3.1.4.17"@en, "cGMP-PDE gamma Subunit"@en, "EC 3.1.4.35"@fr, "EC 3.1.4.35"@en, "Sous-unité alpha des phosphodiestérases des nucléotides cycliques de type 6"@fr, "PDE6, delta Subunit"@en, "Sous-unité gamma des phosphodiestérases des nucléotides cycliques de type VI"@fr, "Sous-unité bêta des phosphodiestérases des nucléotides cycliques de type 6"@fr, "Sous-unité delta de la phosphodiestérase rétinienne"@fr, "Sous-unité delta de PDE6"@fr, "Sous-unité bêta des phosphodiestérases des nucléotides cycliques de type VI"@fr, "Sous-unité gamma de la GMPc phosphodiestérase"@fr, "Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit"@fr, "Sous-unité bêta de la phosphodiestérase rétinienne"@fr, "Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit"@en, "Sous-unité bêta de PDE6"@fr, "PDE6, beta Subunit"@en, "cGMP Phosphodiesterase delta Subunit"@en, "Retinal Phosphodiesterase, alpha Subunit"@en, "Sous-unité delta des PDE de type 6"@fr, "Sous-unité gamma de GMPc-PDE"@fr, "Rod cGMP Phosphodiesterase, beta Subunit"@en, "Retinal Phosphodiesterase, beta Subunit"@en, "Retinal Phosphodiesterase, delta Subunit"@en, "Sous-unité delta des phosphodiestérases des nucléotides cycliques de type VI"@fr, "Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit"@en, "Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit"@fr ; mesh:allowableQualifier jvr:-FWD2BGQ0-9, jvr:-Z9TSGBXH-4, jvr:-Q3979798-W, jvr:-BT300B3G-Q, jvr:-TJHVZCRZ-0, jvr:-SBNWSM1T-R, jvr:-D0F21513-5, jvr:-NB0XHT3S-N, jvr:-XV06LPML-W, jvr:-H7K65Q8S-Z, jvr:-L6C0XPHT-4, jvr:-CB30NGKB-3, jvr:-T2TS0S41-N, jvr:-HQRFT0C6-B, jvr:-WK5F724J-1, jvr:-N2WP45CN-V, jvr:-NHL3D2X0-S, jvr:-NKM836P1-M, jvr:-WZF2ZR3L-B, jvr:-T9HQD7ST-J, jvr:-S0CS1X5R-5, jvr:-CJXMKG5Q-F, jvr:-THHNVC7V-3, jvr:-R3QWLHRG-V, jvr:-G7KXQWSR-5, jvr:-W6SQV79N-S, jvr:-NFTHND7Q-8, jvr:-G30ZJ446-J, jvr:-M63HSDM7-1 ; skos:broader jvr:-DKWV9S7T-9, jvr:-P7BBLCJT-3 ; mesh:registryNumber "EC 3.1.4.17", "EC 3.1.4.35" ; skos:altLabel "Phosphodiestérase-6"@fr, "Phosphodiesterase 6"@en, "Phosphodiestérase PDE6"@fr, "Retinal Phosphodiesterase 6"@en, "Phosphodiesterase Type 6"@en, "PDE des photorécepteurs spécifiques de GMPc de type 6"@fr, "PDE de type 6"@fr, "PDE6 Phosphodiesterases"@en, "Phosphodiestérases des nucléotides cycliques de type VI"@fr, "Phosphodiestérases des nucléotides cycliques de type 6"@fr, "Phosphodiestérase-6 rétinienne"@fr, "Phosphodiestérase VI"@fr ; skos:definition "A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme."@en ; skos:inScheme jvr: ; a skos:Concept, mesh:Descriptor ; dc:established "2008-01-01"^^xsd:date ; skos:prefLabel "Cyclic Nucleotide Phosphodiesterases, Type 6"@en, "Cyclic Nucleotide Phosphodiesterases, Type 6"@fr ; dc:modified "2021-05-21"^^xsd:date ; dc:created "2007-07-09"^^xsd:date ; owl:sameAs . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-DKWV9S7T-9 skos:prefLabel "3',5'-Cyclic-GMP Phosphodiesterases"@fr, "3',5'-Cyclic-GMP Phosphodiesterases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-XDQ2DK5G-H . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-P7BBLCJT-3 skos:prefLabel "3',5'-Cyclic-AMP Phosphodiesterases"@fr, "3',5'-Cyclic-AMP Phosphodiesterases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-XDQ2DK5G-H . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .