@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-XB7BBVD9-P
  skos:hiddenLabel "Chaine légère du facteur VIIIa"@fr, "Factor VIIIa Heavy Chain, 200 kDa Isoform"@en, "Isoforme de 200kDa de la chaîne lourde du facteur VIIIa"@fr, "Factor VIIIa Heavy Chain, 92 kDa Isoform"@en, "Isoforme de 92kDa de la chaîne lourde du facteur VIIIa"@fr, "Chaîne légère du facteur VIIIa"@fr, "Factor VIIIa Light Chain"@en, "Isoforme de 200kDa de la chaine lourde du facteur VIIIa"@fr, "Isoforme de 92kDa de la chaine lourde du facteur VIIIa"@fr ;
  skos:altLabel "Factor Eight A"@en, "Blood Coagulation Factor VIII, Activated"@en, "Factor VIII, Thrombin-Activated"@en, "Blood-coagulation factor VIIIa, procoagulant"@fr, "Blood-coagulation factor VIIIa, procoagulant"@en, "Factor VIII, Activated"@en, "Factor 8A"@en, "Coagulation Factor VIIIa"@en, "Facteur VIII activé"@fr, "Facteur antihémophilique A activé"@fr, "Facteur VIII activé par la thrombine"@fr, "Facteur VIIIa de la coagulation"@fr, "72175-66-7"@fr, "72175-66-7"@en, "Facteur VIIIa de la coagulation sanguine"@fr ;
  mesh:allowableQualifier jvr:-T2TS0S41-N, jvr:-Z9TSGBXH-4, jvr:-G7KXQWSR-5, jvr:-SBNWSM1T-R, jvr:-XV06LPML-W, jvr:-CB30NGKB-3, jvr:-D0F21513-5, jvr:-H7K65Q8S-Z, jvr:-THHNVC7V-3, jvr:-HQRFT0C6-B, jvr:-FWD2BGQ0-9, jvr:-L6C0XPHT-4, jvr:-WK5F724J-1, jvr:-NFTHND7Q-8, jvr:-N2WP45CN-V, jvr:-R0ZCQ8X6-J, jvr:-Q3979798-W, jvr:-T9HQD7ST-J, jvr:-BT300B3G-Q, jvr:-G30ZJ446-J, jvr:-NKM836P1-M, jvr:-NB0XHT3S-N, jvr:-R3QWLHRG-V, jvr:-S0CS1X5R-5, jvr:-WZF2ZR3L-B, jvr:-W6SQV79N-S, jvr:-M63HSDM7-1, jvr:-TJHVZCRZ-0 ;
  skos:definition "Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va."@en ;
  dc:created "1989-05-25"^^xsd:date ;
  skos:related jvr:-SBHXTKJ4-2 ;
  skos:inScheme jvr: ;
  dc:modified "2019-05-30"^^xsd:date ;
  skos:prefLabel "Factor VIIIa"@en, "Facteur VIIIa"@fr ;
  skos:broader jvr:-LWNTJNKQ-7 ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D015944> ;
  dc:established "1990-01-01"^^xsd:date ;
  a skos:Concept, mesh:Descriptor .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-LWNTJNKQ-7
  skos:prefLabel "Facteur VIII"@fr, "Factor VIII"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-XB7BBVD9-P .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-SBHXTKJ4-2
  skos:prefLabel "Coagulants"@fr, "Coagulants"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-XB7BBVD9-P .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .