@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-XQ8VQ4VS-L
  skos:prefLabel "Gene Dosage"@en, "Dosage génique"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-X53PRGP1-5 .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-C0K9WRPB-X
  skos:prefLabel "Mutagenèse"@fr, "Mutagenesis"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-X53PRGP1-5 .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZQHHRF1-F
  skos:prefLabel "Régulation de l'expression des gènes"@fr, "Gene Expression Regulation"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-X53PRGP1-5 .

jvr:-X53PRGP1-5
  mesh:allowableQualifier jvr:-PPKJKFKK-V, jvr:-WZF2ZR3L-B, jvr:-N2WP45CN-V, jvr:-S0CS1X5R-5, jvr:-H7K65Q8S-Z, jvr:-Z9TSGBXH-4 ;
  skos:altLabel "Amplification génique"@fr ;
  skos:definition "A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication."@en ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D005784> ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-Z5N478GX-B, jvr:-WZQHHRF1-F, jvr:-C0K9WRPB-X ;
  dc:modified "2016-06-17"^^xsd:date ;
  skos:related jvr:-XQ8VQ4VS-L ;
  skos:prefLabel "Amplification de gène"@fr, "Gene Amplification"@en ;
  dc:established "1980-01-01"^^xsd:date ;
  dc:created "1979-04-17"^^xsd:date ;
  skos:inScheme jvr: .

jvr:-PPKJKFKK-V
  skos:prefLabel "ethics (Qualifier)"@en, "éthique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z5N478GX-B
  skos:prefLabel "Mutation"@fr, "Mutation"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-X53PRGP1-5 .

jvr: a skos:ConceptScheme .