@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-X7R80Z8F-W skos:prefLabel "Antagonistes des récepteurs purinergiques P1"@fr, "Purinergic P1 Receptor Antagonists"@en ; a mesh:Descriptor, skos:Concept . jvr:-NDXHDQHM-7 skos:prefLabel "Xanthines"@fr, "Xanthines"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-WNXKNPMP-V . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WXBNMBJ8-G skos:prefLabel "Café"@fr, "Coffee"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-WNXKNPMP-V . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G36QLBD8-4 skos:prefLabel "Central Nervous System Stimulants"@en, "Stimulants du système nerveux central"@fr ; a mesh:Descriptor, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G4R176S9-J skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WNXKNPMP-V mesh:allowableQualifier jvr:-TJHVZCRZ-0, jvr:-W6SQV79N-S, jvr:-M63HSDM7-1, jvr:-G30ZJ446-J, jvr:-NKM836P1-M, jvr:-G4R176S9-J, jvr:-WK5F724J-1, jvr:-NB0XHT3S-N, jvr:-THHNVC7V-3, jvr:-Z9TSGBXH-4, jvr:-NHL3D2X0-S, jvr:-D0F21513-5, jvr:-H7K65Q8S-Z, jvr:-XV06LPML-W, jvr:-BT300B3G-Q, jvr:-Q3979798-W, jvr:-R3QWLHRG-V, jvr:-FWD2BGQ0-9, jvr:-SBNWSM1T-R, jvr:-HQRFT0C6-B, jvr:-R0ZCQ8X6-J, jvr:-G7KXQWSR-5, jvr:-T9HQD7ST-J, jvr:-NFTHND7Q-8, jvr:-CB30NGKB-3, jvr:-L6C0XPHT-4, jvr:-S0CS1X5R-5 ; skos:hiddenLabel "No Doz"@en, "Durvitan"@en, "Percoffedrinol N"@en, "Coffeinum Purrum"@en, "Dexitac"@en, "Vivarin"@en, "Quick-Pep"@en, "Coffeinum N"@en, "Percutaféine"@en, "Caffedrine"@en ; dc:created "1999-01-01"^^xsd:date ; mesh:pharmacologicalAction jvr:-FTW031X6-M, jvr:-X7R80Z8F-W, jvr:-G36QLBD8-4 ; dc:established "1966-01-01"^^xsd:date ; dc:modified "2017-05-24"^^xsd:date ; skos:broader jvr:-NDXHDQHM-7 ; skos:altLabel "3G6A5W338E"@en, "3G6A5W338E"@fr, "1,3,7-Trimethylxanthine"@en, "1,3,7-Triméthyl-xanthine"@fr, "58-08-2 (Caffeine)"@fr, "58-08-2 (Caffeine)"@en, "1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-"@en, "1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-"@fr ; a skos:Concept, mesh:Descriptor ; skos:related jvr:-WXBNMBJ8-G ; skos:inScheme jvr: ; skos:prefLabel "Caffeine"@en, "Caféine"@fr ; skos:definition "A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling."@en ; owl:sameAs . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-FTW031X6-M skos:prefLabel "Inhibiteurs de la phosphodiestérase"@fr, "Phosphodiesterase Inhibitors"@en ; a mesh:Descriptor, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .