@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WM85T49F-5
  mesh:allowableQualifier jvr:-THHNVC7V-3, jvr:-TJHVZCRZ-0, jvr:-G4R176S9-J, jvr:-FWD2BGQ0-9, jvr:-L6C0XPHT-4, jvr:-M63HSDM7-1, jvr:-WK5F724J-1, jvr:-XV06LPML-W, jvr:-NHL3D2X0-S, jvr:-W6SQV79N-S, jvr:-R0ZCQ8X6-J, jvr:-T9HQD7ST-J, jvr:-NB0XHT3S-N, jvr:-G30ZJ446-J, jvr:-HQRFT0C6-B, jvr:-NFTHND7Q-8, jvr:-SBNWSM1T-R, jvr:-H7K65Q8S-Z, jvr:-CB30NGKB-3, jvr:-NKM836P1-M, jvr:-BT300B3G-Q, jvr:-D0F21513-5, jvr:-R3QWLHRG-V, jvr:-Q3979798-W, jvr:-S0CS1X5R-5 ;
  dc:created "1983-03-11"^^xsd:date ;
  a mesh:Descriptor, skos:Concept ;
  skos:hiddenLabel "R41400"@fr, "R41400"@en, "R41,400"@fr, "R41,400"@en, "R-41400"@fr, "R-41400"@en, "Nizoral"@en ;
  skos:altLabel "65277-42-1 (Ketoconazole)"@fr, "65277-42-1 (Ketoconazole)"@en, "R9400W927I"@fr, "R9400W927I"@en, "Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-"@fr, "Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-"@en ;
  dc:established "1984-01-01"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D007654> ;
  dc:modified "2017-05-24"^^xsd:date ;
  skos:prefLabel "Kétoconazole"@fr, "Ketoconazole"@en ;
  skos:definition "Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients."@en ;
  mesh:pharmacologicalAction jvr:-MCXK29NN-K, jvr:-S4W4PP2L-8, jvr:-DV1BPDDG-0 ;
  skos:broader jvr:-ZSFBN4K6-W ;
  skos:inScheme jvr: .

jvr:-S4W4PP2L-8
  skos:prefLabel "Cytochrome P-450 CYP3A Inhibitors"@en, "Inhibiteurs du cytochrome P-450 CYP3A"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-MCXK29NN-K
  skos:prefLabel "Antifongiques"@fr, "Antifungal Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-DV1BPDDG-0
  skos:prefLabel "Inhibiteurs de la 14-alpha déméthylase"@fr, "14-alpha Demethylase Inhibitors"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-ZSFBN4K6-W
  skos:prefLabel "Piperazines"@en, "Pipérazines"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-WM85T49F-5 .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .