@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-VSKNTLJ4-D
  mesh:allowableQualifier jvr:-SBNWSM1T-R, jvr:-D0F21513-5, jvr:-FWD2BGQ0-9, jvr:-R3QWLHRG-V, jvr:-XV06LPML-W, jvr:-R0ZCQ8X6-J, jvr:-T9HQD7ST-J, jvr:-NB0XHT3S-N, jvr:-W6SQV79N-S, jvr:-Q3979798-W, jvr:-NFTHND7Q-8, jvr:-NHL3D2X0-S, jvr:-L6C0XPHT-4, jvr:-CB30NGKB-3, jvr:-BT300B3G-Q, jvr:-S0CS1X5R-5, jvr:-G4R176S9-J, jvr:-HQRFT0C6-B, jvr:-TJHVZCRZ-0, jvr:-G30ZJ446-J, jvr:-NKM836P1-M, jvr:-H7K65Q8S-Z, jvr:-M63HSDM7-1, jvr:-THHNVC7V-3, jvr:-WK5F724J-1 ;
  skos:hiddenLabel "HWA 486"@en, "HWA-486"@fr, "HWA-486"@en, "Arava"@en, "SU101"@fr, "SU101"@en ;
  dc:created "2018-07-09"^^xsd:date ;
  skos:broader jvr:-DSTR114N-6 ;
  dc:modified "2018-02-27"^^xsd:date ;
  skos:inScheme jvr: ;
  mesh:pharmacologicalAction jvr:-RNN9WKG8-L, jvr:-H8LJ47P7-S ;
  skos:altLabel "4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-"@fr, "4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-"@en, "G162GK9U4W"@en, "G162GK9U4W"@fr, "N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide"@en, "75706-12-6 (Leflunomide)"@fr, "75706-12-6 (Leflunomide)"@en ;
  a skos:Concept, mesh:Descriptor ;
  skos:prefLabel "Léflunomide"@fr, "Leflunomide"@en ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000077339> ;
  dc:established "2019-01-01"^^xsd:date ;
  skos:definition "An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS."@en .

jvr:-DSTR114N-6
  skos:prefLabel "Isoxazoles"@fr, "Isoxazoles"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-VSKNTLJ4-D .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H8LJ47P7-S
  skos:prefLabel "Immunosuppresseurs"@fr, "Immunosuppressive Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-RNN9WKG8-L
  skos:prefLabel "Enzyme Inhibitors"@en, "Antienzymes"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .