@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-V8MSN10M-3 skos:prefLabel "Inhibiteurs du cytochrome P-450 CYP2C8"@fr, "Cytochrome P-450 CYP2C8 Inhibitors"@en ; a mesh:Descriptor, skos:Concept . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWBNGBWP-4 skos:prefLabel "Pyrimidines"@fr, "Pyrimidines"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-VJ0X0F6B-B . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-VBLZTN3V-0 skos:prefLabel "Trimethoprim Resistance"@en, "Résistance au triméthoprime"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-VJ0X0F6B-B . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-WC6FH6FQ-K skos:prefLabel "Antidyskinésiques"@fr, "Anti-Dyskinesia Agents"@en ; a mesh:Descriptor, skos:Concept . jvr:-HMPWGQQZ-2 skos:prefLabel "Folic Acid Antagonists"@en, "Antifoliques"@fr ; a mesh:Descriptor, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-W89RF8RP-4 skos:prefLabel "Antipaludiques"@fr, "Antimalarials"@en ; a mesh:Descriptor, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G4R176S9-J skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-VJ0X0F6B-B mesh:allowableQualifier jvr:-Q3979798-W, jvr:-BT300B3G-Q, jvr:-FWD2BGQ0-9, jvr:-TJHVZCRZ-0, jvr:-L6C0XPHT-4, jvr:-NKM836P1-M, jvr:-H7K65Q8S-Z, jvr:-CB30NGKB-3, jvr:-WK5F724J-1, jvr:-XV06LPML-W, jvr:-D0F21513-5, jvr:-M63HSDM7-1, jvr:-G4R176S9-J, jvr:-T9HQD7ST-J, jvr:-NB0XHT3S-N, jvr:-S0CS1X5R-5, jvr:-HQRFT0C6-B, jvr:-W6SQV79N-S, jvr:-R0ZCQ8X6-J, jvr:-THHNVC7V-3, jvr:-G30ZJ446-J, jvr:-NHL3D2X0-S, jvr:-SBNWSM1T-R, jvr:-R3QWLHRG-V, jvr:-NFTHND7Q-8 ; skos:hiddenLabel "Proloprim"@en, "Trimpex"@en ; skos:related jvr:-VBLZTN3V-0 ; skos:inScheme jvr: ; a mesh:Descriptor, skos:Concept ; mesh:pharmacologicalAction jvr:-W89RF8RP-4, jvr:-HMPWGQQZ-2, jvr:-WC6FH6FQ-K, jvr:-MJ5NGK4D-Q, jvr:-V8MSN10M-3 ; skos:broader jvr:-FWBNGBWP-4 ; skos:altLabel "AN164J8Y0X"@fr, "AN164J8Y0X"@en, "738-70-5 (Trimethoprim)"@en, "738-70-5 (Trimethoprim)"@fr, "2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-"@fr, "2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-"@en ; skos:prefLabel "Trimethoprim"@en, "Triméthoprime"@fr ; owl:sameAs ; dc:modified "2018-05-21"^^xsd:date ; skos:narrower jvr:-CK6TT8N4-X ; dc:created "1999-01-01"^^xsd:date ; skos:definition "A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported."@en ; dc:established "1974-01-01"^^xsd:date . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CK6TT8N4-X skos:prefLabel "Trimethoprim, Sulfamethoxazole Drug Combination"@en, "Association triméthoprime-sulfaméthoxazole"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-VJ0X0F6B-B . jvr:-MJ5NGK4D-Q skos:prefLabel "Anti-infectieux urinaires"@fr, "Anti-Infective Agents, Urinary"@en ; a mesh:Descriptor, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .