@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-DBNSQSNK-X skos:prefLabel "Neurotoxines"@fr, "Neurotoxins"@en ; a mesh:Descriptor, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-D72XHVM2-G skos:prefLabel "Clostridium tetani"@en, "Clostridium tetani"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-SWRP5MHF-9 . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-ZQDSD9XK-P skos:prefLabel "Bacterial Toxins"@en, "Toxines bactériennes"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-SWRP5MHF-9 . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-RRFR8MKH-R skos:prefLabel "Bacterial Proteins"@en, "Protéines bactériennes"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-SWRP5MHF-9 . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SWRP5MHF-9 mesh:allowableQualifier jvr:-M63HSDM7-1, jvr:-T9HQD7ST-J, jvr:-WK5F724J-1, jvr:-THHNVC7V-3, jvr:-NB0XHT3S-N, jvr:-W6SQV79N-S, jvr:-Z9TSGBXH-4, jvr:-L6C0XPHT-4, jvr:-D0F21513-5, jvr:-HQRFT0C6-B, jvr:-WZF2ZR3L-B, jvr:-R0ZCQ8X6-J, jvr:-Q3979798-W, jvr:-H7K65Q8S-Z, jvr:-NHL3D2X0-S, jvr:-BT300B3G-Q, jvr:-G30ZJ446-J, jvr:-CB30NGKB-3, jvr:-FWD2BGQ0-9, jvr:-SBNWSM1T-R, jvr:-NKM836P1-M, jvr:-NFTHND7Q-8, jvr:-XV06LPML-W, jvr:-G7KXQWSR-5, jvr:-TJHVZCRZ-0, jvr:-S0CS1X5R-5, jvr:-R3QWLHRG-V ; skos:broader jvr:-RRFR8MKH-R, jvr:-ZQDSD9XK-P ; skos:altLabel "Toxine de Clostridium tetani"@fr, "Tetanus Toxins"@en, "Clostridium tetani Toxin"@en, "Toxine du tétanos"@fr ; dc:modified "2020-05-27"^^xsd:date ; skos:definition "Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS."@en ; owl:sameAs ; a skos:Concept, mesh:Descriptor ; skos:related jvr:-D72XHVM2-G, jvr:-HDTSL8TQ-9 ; mesh:pharmacologicalAction jvr:-DBNSQSNK-X ; skos:prefLabel "Tetanus Toxin"@en, "Toxine tétanique"@fr ; dc:established "1965-01-01"^^xsd:date ; skos:inScheme jvr: ; skos:hiddenLabel "Clostridial Neurotoxin"@en, "Neurotoxine de Clostridium tetani"@fr, "Neurotoxine clostridiale"@fr ; dc:created "1999-01-01"^^xsd:date . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HDTSL8TQ-9 skos:prefLabel "Antitoxine tétanique"@fr, "Tetanus Antitoxin"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-SWRP5MHF-9 .