@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-B18CSWXT-8
  skos:prefLabel "Domaines protéiques"@fr, "Protein Domains"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-SP7PZSTV-3 .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-FPS03PTK-9
  skos:prefLabel "Facteur-1 liant le domaine de régulation positive I"@fr, "Positive Regulatory Domain I-Binding Factor 1"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-SP7PZSTV-3 .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SP7PZSTV-3
  dc:established "2018-01-01"^^xsd:date ;
  a skos:Concept, mesh:Descriptor ;
  skos:inScheme jvr: ;
  skos:hiddenLabel "PR Domain"@en, "Domaine SET"@fr, "SET Domain"@en, "Domaine PR"@fr ;
  skos:prefLabel "Domaines PR-SET"@fr, "PR-SET Domains"@en ;
  mesh:allowableQualifier jvr:-WZF2ZR3L-B, jvr:-N2WP45CN-V, jvr:-H7K65Q8S-Z, jvr:-S0CS1X5R-5, jvr:-Z9TSGBXH-4 ;
  dc:created "2017-07-11"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000074463> ;
  dc:modified "2017-04-05"^^xsd:date ;
  skos:related jvr:-FPS03PTK-9 ;
  skos:broader jvr:-B18CSWXT-8 ;
  skos:definition "Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an \"L\" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a \"knot\". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN."@en .