@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WCPMV90Z-4
  skos:prefLabel "ADAM Proteins"@en, "Protéines ADAM"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-SL3M8DFH-L .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-SL3M8DFH-L
  skos:altLabel "ADAM-17"@fr, "ADAM-17"@en, "Tumor Necrosis Factor Alpha Convertase"@en, "TACE (Enzyme)"@fr, "TACE (Enzyme)"@en, "Convertase du facteur de nécrose tumorale alpha"@fr, "Convertase du TNF-alpha"@fr, "Enzyme de conversion du TNF-alpha"@fr, "TACA (Enzyme)"@fr, "TACA (Enzyme)"@en, "Protéine-17 contenant un domaine désintégrine et un domaine métalloprotéinase"@fr, "Tumor Necrosis Factor-alpha Convertase"@en, "Protéine-17 contenant des domaines désintégrine et métalloprotéinase"@fr, "Protéine ADAM-17"@fr, "CD156b"@fr, "Tumor Necrosis Factor-alpha Converting Enzyme"@en, "Disintegrin and Metalloproteinase Domain-Containing Protein 17"@en, "TNF-alpha Convertase"@en, "Antigène CD156b"@fr, "TNF-alpha Converting Enzyme"@en, "CD156b Antigen"@en, "Enzyme de conversion du facteur de nécrose tumorale alpha"@fr, "ADAM-17 Protein"@en ;
  mesh:allowableQualifier jvr:-NB0XHT3S-N, jvr:-Q3979798-W, jvr:-SBNWSM1T-R, jvr:-NKM836P1-M, jvr:-HQRFT0C6-B, jvr:-FWD2BGQ0-9, jvr:-D0F21513-5, jvr:-T9HQD7ST-J, jvr:-WK5F724J-1, jvr:-NFTHND7Q-8, jvr:-G7KXQWSR-5, jvr:-R3QWLHRG-V, jvr:-G30ZJ446-J, jvr:-CB30NGKB-3, jvr:-M63HSDM7-1, jvr:-TJHVZCRZ-0, jvr:-L6C0XPHT-4, jvr:-THHNVC7V-3, jvr:-S0CS1X5R-5, jvr:-T2TS0S41-N, jvr:-WZF2ZR3L-B, jvr:-W6SQV79N-S, jvr:-Z9TSGBXH-4, jvr:-CJXMKG5Q-F, jvr:-NHL3D2X0-S, jvr:-BT300B3G-Q, jvr:-XV06LPML-W, jvr:-H7K65Q8S-Z, jvr:-N2WP45CN-V ;
  skos:prefLabel "ADAM17 Protein"@en, "Protéine ADAM17"@fr ;
  skos:broader jvr:-WCPMV90Z-4 ;
  dc:modified "2017-05-24"^^xsd:date ;
  skos:definition "A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS."@en ;
  dc:created "2016-07-06"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000072198> ;
  mesh:registryNumber "EC 3.4.24.86" ;
  dc:established "2017-01-01"^^xsd:date ;
  skos:inScheme jvr: ;
  a skos:Concept, mesh:Descriptor ;
  skos:hiddenLabel "EC 3.4.24.86"@fr, "EC 3.4.24.86"@en .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .