@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

jvr:-JGMH1JL1-6
  skos:prefLabel "Receptors, Guanylate Cyclase-Coupled"@en, "Récepteurs à activité guanylate cyclase"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-RT40K0PH-K .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-HG5GSZL0-S
  skos:prefLabel "Entérotoxines"@fr, "Enterotoxins"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-RT40K0PH-K .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-RT40K0PH-K
  mesh:allowableQualifier jvr:-T2TS0S41-N, jvr:-S0CS1X5R-5, jvr:-WZF2ZR3L-B, jvr:-HQRFT0C6-B, jvr:-W6SQV79N-S, jvr:-FWD2BGQ0-9, jvr:-D0F21513-5, jvr:-M63HSDM7-1, jvr:-CJXMKG5Q-F, jvr:-Q3979798-W, jvr:-Z9TSGBXH-4, jvr:-H7K65Q8S-Z, jvr:-N2WP45CN-V, jvr:-SBNWSM1T-R, jvr:-NHL3D2X0-S, jvr:-L6C0XPHT-4, jvr:-TJHVZCRZ-0, jvr:-G7KXQWSR-5 ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000074261> ;
  skos:prefLabel "Récepteurs des entérotoxines"@fr, "Receptors, Enterotoxin"@en ;
  skos:inScheme jvr: ;
  dc:established "2018-01-01"^^xsd:date ;
  skos:broader jvr:-F0WSFZXS-7, jvr:-JGMH1JL1-6 ;
  skos:altLabel "Receptors, Guanyl Cyclase-C"@en, "Enterotoxin Receptors"@en, "Guanyl Cyclase-C Receptor"@en, "GC-C Receptor"@en, "Récepteurs des entérotoxines et de la guanyline"@fr, "Receptor, Guanyl Cyclase-C"@en, "Récepteurs des entérotoxines thermostables"@fr, "Guanylin-Uroguanylin Receptors"@en, "Récepteurs GC-C"@fr, "Enterotoxin-Guanylin Receptor"@en, "Heat-Stable Enterotoxin Receptor"@en, "Guanylin-Uroguanylin Receptor"@en, "Receptor, Enterotoxin"@en, "Récepteurs à activité guanylyl cyclase-C"@fr, "Enterotoxin Receptor"@en, "Guanyl Cyclase-C Receptors"@en, "Guanylyl Cyclase C"@en, "Enterotoxin-Guanylin Receptors"@en, "Heat-Stable Enterotoxin Receptors"@en, "GC-C Receptors"@en, "Récepteurs de la guanyline et de l'uroguanyline"@fr, "Récepteurs à activité guanylate cyclase-C"@fr ;
  a skos:Concept, mesh:Descriptor ;
  skos:definition "Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS."@en ;
  dc:modified "2018-06-20"^^xsd:date ;
  skos:related jvr:-HG5GSZL0-S ;
  dc:created "2017-07-11"^^xsd:date ;
  skos:hiddenLabel "EC 4.6.1.2"@fr, "EC 4.6.1.2"@en ;
  mesh:registryNumber "EC 4.6.1.2" .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-F0WSFZXS-7
  skos:prefLabel "Récepteurs peptidiques"@fr, "Receptors, Peptide"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-RT40K0PH-K .