@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-ZGL5VHG5-9
  skos:prefLabel "Tubulin Modulators"@en, "Modulateurs de la polymérisation de la tubuline"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-QZZ9NMPX-8
  skos:prefLabel "Ado-Trastuzumab Emtansine"@en, "Ado-trastuzumab emtansine"@fr ;
  dc:modified "2019-01-16"^^xsd:date ;
  mesh:allowableQualifier jvr:-W6SQV79N-S, jvr:-N2WP45CN-V, jvr:-L6C0XPHT-4, jvr:-XV06LPML-W, jvr:-S0CS1X5R-5, jvr:-D0F21513-5, jvr:-SBNWSM1T-R, jvr:-T2TS0S41-N, jvr:-NHL3D2X0-S, jvr:-H7K65Q8S-Z, jvr:-NKM836P1-M, jvr:-HQRFT0C6-B, jvr:-CB30NGKB-3, jvr:-Z9TSGBXH-4, jvr:-WK5F724J-1, jvr:-G30ZJ446-J, jvr:-TJHVZCRZ-0, jvr:-BT300B3G-Q, jvr:-NB0XHT3S-N, jvr:-FWD2BGQ0-9, jvr:-Q3979798-W, jvr:-NFTHND7Q-8 ;
  skos:altLabel "SE2KH7T06F"@fr, "SE2KH7T06F"@en, "Trastuzumab Emtansine"@en, "Trastuzumab Emtansine"@fr ;
  dc:established "2020-01-01"^^xsd:date ;
  mesh:pharmacologicalAction jvr:-TKX12FSH-F, jvr:-V4497M3G-4, jvr:-ZGL5VHG5-9 ;
  a mesh:Descriptor, skos:Concept ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000080044> ;
  skos:broader jvr:-VTZC3XNN-0, jvr:-CVCBN1XG-B ;
  skos:hiddenLabel "Trastuzumab-DM1"@en, "Trastuzumab-DM1"@fr, "huN901-DM1"@en, "Trastuzumab-DM1 Conjugate"@en, "Anticorps conjugué trastuzumab-DM1"@fr, "Kadcyla"@en ;
  skos:inScheme jvr: ;
  dc:created "2019-07-08"^^xsd:date ;
  skos:definition "Immunotoxin that consists of humanized monoclonal anti-HER2 antibody TRASTUZUMAB covalently linked to anti-microtubule agent MAYTANSINOID DM1 for treatment of metastatic breast cancer in patients who previously received trastuzumab and a TAXANES, separately or in combination."@en .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CVCBN1XG-B
  skos:prefLabel "Trastuzumab"@fr, "Trastuzumab"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-QZZ9NMPX-8 .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-VTZC3XNN-0
  skos:prefLabel "Maytansine"@en, "Maitansine"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-QZZ9NMPX-8 .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-TKX12FSH-F
  skos:prefLabel "Immunotoxines"@fr, "Immunotoxins"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-V4497M3G-4
  skos:prefLabel "Antineoplastic Agents, Immunological"@en, "Antinéoplasiques immunologiques"@fr ;
  a mesh:Descriptor, skos:Concept .