@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-CGCP4DFF-R skos:prefLabel "Mixed Function Oxygenases"@en, "Mixed function oxygenases"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-QW6NM13W-2 . jvr:-ZXD1D13Q-X skos:prefLabel "Cytochrome P450 Family 2"@en, "Famille-2 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-HDSG0HS3-Z skos:prefLabel "CYP2J2 du cytochrome P450"@fr, "Cytochrome P-450 CYP2J2"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-W080QM1D-L skos:prefLabel "Cytochrome P450 Family 11"@en, "Famille-11 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-CZDH7T87-D skos:prefLabel "Famille-27 de cytochromes P450"@fr, "Cytochrome P450 Family 27"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-K7JXQNZ3-L skos:prefLabel "Famille-21 de cytochromes P450"@fr, "Cytochrome P450 Family 21"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKGW09F4-P skos:prefLabel "Cytochrome P450 Family 7"@en, "Famille-7 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-GWT0SBNS-T skos:prefLabel "Cytochrome P450 Family 19"@en, "Famille-19 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W8F21ZVX-H skos:prefLabel "Famille-46 de cytochromes P450"@fr, "Cytochrome P450 Family 46"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-J0W2KLT0-R skos:prefLabel "Cytochrome P450 Family 8"@en, "Famille-8 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H223424B-W skos:prefLabel "Steroid hydroxylases"@fr, "Steroid Hydroxylases"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-SX39FBJW-8 skos:prefLabel "Famille-6 de cytochromes P450"@fr, "Cytochrome P450 Family 6"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-DLQM3XMT-J skos:prefLabel "Famille-3 de cytochromes P450"@fr, "Cytochrome P450 Family 3"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-PW3ZLVZH-M skos:prefLabel "Cytochromes"@fr, "Cytochromes"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-QW6NM13W-2 . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-ZG0BL98D-3 skos:prefLabel "Trans-cinnamate 4-monooxygenase"@fr, "Trans-Cinnamate 4-Monooxygenase"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-QW6NM13W-2 skos:altLabel "Cytochrome P-450 Families"@en, "Cytochrome P-450 Enzymes"@en, "Cytochrome P-450"@en, "P-450 Enzyme"@en, "Cytochrome P-450 Enzyme"@en, "Système cytochrome P450"@fr, "Cytochrome P450"@en, "9035-51-2"@fr, "9035-51-2"@en, "Cytochrome P450 Superfamily"@en, "CYP450 Family"@en, "P450 Enzyme"@en, "CYP450 Superfamily"@en, "P-450 Enzymes"@en, "P450 Enzymes"@en, "Cytochrome P 450"@fr, "Cytochrome P 450"@en, "Système enzymatique du cytochrome P-450"@fr, "Cytochrome P-450 Superfamily"@en, "Cytochrome p450 Families"@en ; skos:narrower jvr:-ZJXXGZ1B-L, jvr:-Z5PBDGXG-S, jvr:-RLJVQ9Q5-Z, jvr:-ZXD1D13Q-X, jvr:-PGMMGZ5S-R, jvr:-SX39FBJW-8, jvr:-V0G8NF0R-D, jvr:-H223424B-W, jvr:-CZDH7T87-D, jvr:-NKGW09F4-P, jvr:-DLQM3XMT-J, jvr:-XCK77WC3-7, jvr:-TDFBC4CM-J, jvr:-ZG0BL98D-3, jvr:-K7JXQNZ3-L, jvr:-W080QM1D-L, jvr:-BXB7FHGP-5, jvr:-W8F21ZVX-H, jvr:-WRDHVBW7-4, jvr:-J0W2KLT0-R, jvr:-HDSG0HS3-Z, jvr:-GWT0SBNS-T ; mesh:allowableQualifier jvr:-L6C0XPHT-4, jvr:-FWD2BGQ0-9, jvr:-H7K65Q8S-Z, jvr:-Z9TSGBXH-4, jvr:-D0F21513-5, jvr:-WZF2ZR3L-B, jvr:-XV06LPML-W, jvr:-Q3979798-W, jvr:-G7KXQWSR-5, jvr:-CB30NGKB-3, jvr:-NKM836P1-M, jvr:-TJHVZCRZ-0, jvr:-HQRFT0C6-B, jvr:-BT300B3G-Q, jvr:-R3QWLHRG-V, jvr:-WK5F724J-1, jvr:-THHNVC7V-3, jvr:-T9HQD7ST-J, jvr:-N2WP45CN-V, jvr:-W6SQV79N-S, jvr:-G30ZJ446-J, jvr:-NFTHND7Q-8, jvr:-S0CS1X5R-5, jvr:-CJXMKG5Q-F, jvr:-NHL3D2X0-S, jvr:-T2TS0S41-N, jvr:-SBNWSM1T-R, jvr:-NB0XHT3S-N ; skos:prefLabel "Cytochrome P-450 Enzyme System"@en, "Cytochrome P-450 enzyme system"@fr ; a mesh:Descriptor, skos:Concept ; owl:sameAs ; dc:created "1999-01-01"^^xsd:date ; skos:hiddenLabel "Cytochrome P-450 oxygenase"@fr, "Cytochrome P-450 monooxygenase"@fr, "Cytochrome P-450 Oxygenase"@en, "Cytochrome P-450 Monooxygenase"@en, "Cytochrome P-450-Dependent Monooxygenase"@en ; skos:broader jvr:-PW3ZLVZH-M, jvr:-CGCP4DFF-R ; skos:definition "A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism."@en ; dc:established "1973-01-01"^^xsd:date ; skos:inScheme jvr: ; dc:modified "2020-05-27"^^xsd:date . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-RLJVQ9Q5-Z skos:prefLabel "Famille-26 de cytochromes P450"@fr, "Cytochrome P450 Family 26"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-ZJXXGZ1B-L skos:prefLabel "Aryl Hydrocarbon Hydroxylases"@en, "Aryl hydrocarbon hydroxylases"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-XCK77WC3-7 skos:prefLabel "Camphor 5-Monooxygenase"@en, "Camphor 5-monooxygenase"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-Z5PBDGXG-S skos:prefLabel "Cytochrome P450 Family 1"@en, "Famille-1 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-V0G8NF0R-D skos:prefLabel "Famille-24 de cytochromes P450"@fr, "Cytochrome P450 Family 24"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-WRDHVBW7-4 skos:prefLabel "Famille-17 de cytochromes P450"@fr, "Cytochrome P450 Family 17"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-PGMMGZ5S-R skos:prefLabel "Famille-4 de cytochromes P450"@fr, "Cytochrome P450 Family 4"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-TDFBC4CM-J skos:prefLabel "Cytochrome P450 Family 51"@en, "Famille-51 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-BXB7FHGP-5 skos:prefLabel "Cytochrome P450 Family 12"@en, "Famille-12 de cytochromes P450"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-QW6NM13W-2 .