@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-DK0ZH052-L
  skos:prefLabel "Anti-Asthmatic Agents"@en, "Antiasthmatiques"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-PFLXXSV3-F
  skos:prefLabel "Anti-Allergic Agents"@en, "Antiallergiques"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-QS194GCH-N
  a skos:Concept, mesh:Descriptor ;
  mesh:allowableQualifier jvr:-H7K65Q8S-Z, jvr:-S0CS1X5R-5, jvr:-G30ZJ446-J, jvr:-HQRFT0C6-B, jvr:-SBNWSM1T-R, jvr:-T2TS0S41-N, jvr:-L6C0XPHT-4, jvr:-NKM836P1-M, jvr:-NB0XHT3S-N, jvr:-BT300B3G-Q, jvr:-Z9TSGBXH-4, jvr:-NFTHND7Q-8, jvr:-XV06LPML-W, jvr:-WK5F724J-1, jvr:-CB30NGKB-3, jvr:-WZF2ZR3L-B, jvr:-W6SQV79N-S, jvr:-Q3979798-W, jvr:-D0F21513-5, jvr:-FWD2BGQ0-9, jvr:-TJHVZCRZ-0, jvr:-N2WP45CN-V, jvr:-G7KXQWSR-5, jvr:-NHL3D2X0-S ;
  mesh:pharmacologicalAction jvr:-DK0ZH052-L, jvr:-PFLXXSV3-F ;
  skos:definition "An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA."@en ;
  skos:altLabel "242138-07-4"@en, "242138-07-4"@fr, "2P471X1Z11"@fr, "2P471X1Z11"@en, "Immunoglobulin G, anti-(human immunoglobulin E Fc region)(human-mouse monoclonal E25 clone pSVIE26 gamma-chain), disulfide with human-mouse monoclonal E25 clone pSVIE26 kappa-chain, dimer"@fr, "Immunoglobulin G, anti-(human immunoglobulin E Fc region)(human-mouse monoclonal E25 clone pSVIE26 gamma-chain), disulfide with human-mouse monoclonal E25 clone pSVIE26 kappa-chain, dimer"@en ;
  skos:inScheme jvr: ;
  skos:hiddenLabel "Xolair"@fr, "Xolair"@en ;
  skos:broader jvr:-MR3FF387-P, jvr:-NJHH5T6R-L ;
  skos:prefLabel "Omalizumab"@en, "Omalizumab"@fr ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000069444> ;
  dc:established "2016-01-01"^^xsd:date ;
  dc:modified "2017-06-20"^^xsd:date ;
  dc:created "2015-07-01"^^xsd:date .

jvr: a skos:ConceptScheme .
jvr:-MR3FF387-P
  skos:prefLabel "Anticorps anti-idiotypiques"@fr, "Antibodies, Anti-Idiotypic"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-QS194GCH-N .

jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NJHH5T6R-L
  skos:prefLabel "Anticorps monoclonaux humanisés"@fr, "Antibodies, Monoclonal, Humanized"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-QS194GCH-N .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .