@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-JTN1XC66-6
  skos:prefLabel "Enchevêtrements neurofibrillaires"@fr, "Neurofibrillary Tangles"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-Q9ZX3ZGS-X .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R8VHV50Q-3
  skos:prefLabel "Intermediate Filament Proteins"@en, "Protéines de filaments intermédiaires"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-Q9ZX3ZGS-X .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M44KSRMV-J
  skos:prefLabel "Nerve Tissue Proteins"@en, "Protéines de tissu nerveux"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-Q9ZX3ZGS-X .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-KPNCFB5S-5
  skos:prefLabel "Maladie d'Alzheimer"@fr, "Alzheimer Disease"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-Q9ZX3ZGS-X .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q9ZX3ZGS-X
  skos:hiddenLabel "Neurofilament Triplet Proteins"@en, "Sous-unité lourde des neurofilaments"@fr, "Chaîne lourde du neurofilament"@fr, "Sous-unité lourde de neurofilament"@fr, "Triplet de protéines neurofilamenteuses"@fr, "Trois protéines de neurofilaments"@fr, "Heavy Neurofilament Protein"@en ;
  mesh:allowableQualifier jvr:-L6C0XPHT-4, jvr:-Z9TSGBXH-4, jvr:-H7K65Q8S-Z, jvr:-FWD2BGQ0-9, jvr:-G30ZJ446-J, jvr:-CJXMKG5Q-F, jvr:-THHNVC7V-3, jvr:-XV06LPML-W, jvr:-BT300B3G-Q, jvr:-Q3979798-W, jvr:-NB0XHT3S-N, jvr:-T9HQD7ST-J, jvr:-NHL3D2X0-S, jvr:-NFTHND7Q-8, jvr:-W6SQV79N-S, jvr:-WK5F724J-1, jvr:-M63HSDM7-1, jvr:-D0F21513-5, jvr:-WZF2ZR3L-B, jvr:-N2WP45CN-V, jvr:-TJHVZCRZ-0, jvr:-T2TS0S41-N, jvr:-CB30NGKB-3, jvr:-S0CS1X5R-5, jvr:-HQRFT0C6-B, jvr:-NKM836P1-M, jvr:-R0ZCQ8X6-J, jvr:-SBNWSM1T-R, jvr:-R3QWLHRG-V, jvr:-G7KXQWSR-5 ;
  skos:definition "Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)"@en ;
  skos:broader jvr:-M44KSRMV-J, jvr:-R8VHV50Q-3 ;
  skos:related jvr:-KPNCFB5S-5, jvr:-JTN1XC66-6 ;
  a mesh:Descriptor, skos:Concept ;
  skos:prefLabel "Protéines neurofilamenteuses"@fr, "Neurofilament Proteins"@en ;
  skos:altLabel "Neurofilament Protein"@en, "Protéines des neurofilaments"@fr, "Protéines neurofibrillaires"@fr ;
  dc:established "1992-01-01"^^xsd:date ;
  dc:created "1991-05-30"^^xsd:date ;
  skos:inScheme jvr: ;
  dc:modified "2020-06-17"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D016900> .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .