@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-RXK471D5-C
  skos:prefLabel "Récepteurs de LDL oxydées"@fr, "Receptors, Oxidized LDL"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P85MNZ1S-1 .

jvr:-J25266DS-T
  skos:prefLabel "Receptors, Scavenger"@en, "Récepteurs éboueurs"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P85MNZ1S-1 .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FGXH4HC7-8
  skos:prefLabel "LDL-Receptor Related Proteins"@en, "Protéines apparentées au récepteur LDL"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P85MNZ1S-1 .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-BG1ZRJ43-0
  skos:prefLabel "Hypercholestérolémie familiale homozygote"@fr, "Homozygous Familial Hypercholesterolemia"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-P85MNZ1S-1 .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-P85MNZ1S-1
  mesh:allowableQualifier jvr:-G7KXQWSR-5, jvr:-L6C0XPHT-4, jvr:-D0F21513-5, jvr:-TJHVZCRZ-0, jvr:-W6SQV79N-S, jvr:-Q3979798-W, jvr:-H7K65Q8S-Z, jvr:-Z9TSGBXH-4, jvr:-CJXMKG5Q-F, jvr:-N2WP45CN-V, jvr:-FWD2BGQ0-9, jvr:-HQRFT0C6-B, jvr:-WZF2ZR3L-B, jvr:-T2TS0S41-N, jvr:-M63HSDM7-1, jvr:-S0CS1X5R-5, jvr:-NHL3D2X0-S, jvr:-SBNWSM1T-R, jvr:-R0ZCQ8X6-J ;
  skos:narrower jvr:-J25266DS-T, jvr:-RXK471D5-C, jvr:-FGXH4HC7-8 ;
  skos:related jvr:-BG1ZRJ43-0, jvr:-HCJ43BXX-V ;
  skos:broader jvr:-G1ZNQN88-R ;
  skos:altLabel "LDL Receptors, Lipoprotein"@en, "LDL Receptors"@en, "Récepteurs aux lipoprotéines de faible densité"@fr, "Lipoprotein LDL Receptors"@en, "Low Density Lipoprotein Receptor"@en, "Récepteurs LDLR"@fr, "Récepteurs aux LDL"@fr, "Low Density Lipoprotein Receptors"@en, "Récepteurs aux lipoprotéines de basse densité"@fr, "Receptors, Low Density Lipoprotein"@en, "Récepteurs des lipoprotéines LDL"@fr, "Receptors, Lipoprotein, LDL"@en, "LDL Receptor"@en, "Récepteurs des LDL"@fr ;
  dc:established "1985-01-01"^^xsd:date ;
  a skos:Concept, mesh:Descriptor ;
  skos:prefLabel "Receptors, LDL"@en, "Récepteurs aux lipoprotéines LDL"@fr ;
  skos:inScheme jvr: ;
  skos:definition "Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking."@en ;
  dc:modified "2006-07-05"^^xsd:date ;
  dc:created "1984-05-25"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D011973> .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HCJ43BXX-V
  skos:prefLabel "Lipoproteins, LDL"@en, "Lipoprotéines LDL"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-P85MNZ1S-1 .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G1ZNQN88-R
  skos:prefLabel "Receptors, Lipoprotein"@en, "Récepteurs aux lipoprotéines"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-P85MNZ1S-1 .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .