@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-QN5NPL30-1 skos:prefLabel "Angioedème héréditaire de type III"@fr, "Hereditary Angioedema Type III"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-P6Z58324-4 . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-PMKD9L6P-C skos:prefLabel "Factor XIIa"@en, "Facteur XIIa"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-P6Z58324-4 . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-SLRV20SS-3 skos:prefLabel "Enzyme Precursors"@en, "Proenzymes"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-P6Z58324-4 . jvr:-P6Z58324-4 owl:sameAs ; skos:definition "Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III."@en ; skos:altLabel "Facteur XII de la coagulation"@fr, "9001-30-3"@fr, "9001-30-3"@en, "Factor 12"@en, "Hageman Factor"@en, "Facteur Hageman"@fr, "Factor Twelve"@en, "Blood-coagulation factor XII"@fr, "Blood-coagulation factor XII"@en, "Facteur de Hageman"@fr, "Facteur XII de la coagulation sanguine"@fr, "Coagulation Factor XII"@en ; mesh:allowableQualifier jvr:-G30ZJ446-J, jvr:-HQRFT0C6-B, jvr:-BT300B3G-Q, jvr:-CB30NGKB-3, jvr:-NB0XHT3S-N, jvr:-H7K65Q8S-Z, jvr:-NKM836P1-M, jvr:-N2WP45CN-V, jvr:-FWD2BGQ0-9, jvr:-THHNVC7V-3, jvr:-T9HQD7ST-J, jvr:-TJHVZCRZ-0, jvr:-XV06LPML-W, jvr:-L6C0XPHT-4, jvr:-M63HSDM7-1, jvr:-R3QWLHRG-V, jvr:-G7KXQWSR-5, jvr:-NFTHND7Q-8, jvr:-SBNWSM1T-R, jvr:-T2TS0S41-N, jvr:-S0CS1X5R-5, jvr:-WK5F724J-1, jvr:-Q3979798-W, jvr:-WZF2ZR3L-B, jvr:-D0F21513-5, jvr:-Z9TSGBXH-4, jvr:-W6SQV79N-S, jvr:-R0ZCQ8X6-J ; skos:narrower jvr:-PMKD9L6P-C ; skos:broader jvr:-L31P524H-V, jvr:-SLRV20SS-3 ; skos:prefLabel "Facteur XII"@fr, "Factor XII"@en ; dc:established "1966-01-01"^^xsd:date ; a skos:Concept, mesh:Descriptor ; skos:related jvr:-QN5NPL30-1, jvr:-SBHXTKJ4-2 ; dc:modified "2019-05-30"^^xsd:date ; skos:inScheme jvr: ; dc:created "1999-01-01"^^xsd:date . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L31P524H-V skos:prefLabel "Facteurs de la coagulation sanguine"@fr, "Blood Coagulation Factors"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-P6Z58324-4 . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-SBHXTKJ4-2 skos:prefLabel "Coagulants"@fr, "Coagulants"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-P6Z58324-4 . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .