@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-GQSQKP48-C
  skos:prefLabel "Inhibiteur p16 de kinase cycline-dépendante"@fr, "Cyclin-Dependent Kinase Inhibitor p16"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-RB4M9P09-G
  skos:prefLabel "Inhibiteur p21 de kinase cycline-dépendante"@fr, "Cyclin-Dependent Kinase Inhibitor p21"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-JSW5590K-N
  skos:prefLabel "Protéines du cycle cellulaire"@fr, "Cell Cycle Proteins"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-P5K3DBDP-J .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-P5K3DBDP-J
  skos:hiddenLabel "Protéines inhibitrices de kinase-4 cycline-dépendante"@fr, "Inhibiteurs CIP-KIP de kinases dépendantes de cyclines"@fr, "Inhibiteurs INK4 de kinases dépendantes de cycline"@fr, "CIP-KIP Cyclin-Dependent Kinase Inhibitors"@en, "Protéines CIP-KIP des CDKI"@fr, "Protéines INK4 des CKI"@fr, "Inhibiteurs INK4 de CDK"@fr, "CIP-KIP CDKI Proteins"@en, "Protéines CIP-KIP des CKI"@fr, "Protéines INK4 des CDKI"@fr, "Inhibitors of Cyclin-Dependent Kinase 4 Proteins"@en, "Inhibiteurs CIP-KIP de CDK"@fr, "INK4 CKI Proteins"@en, "Inhibiteurs INK4 de kinases cycline-dépendantes"@fr, "Inhibiteurs CIP-KIP de kinases cyclines-dépendantes"@fr, "CIP-KIP CKI Proteins"@en, "INK4 CDKI Proteins"@en, "INK4 Cyclin-Dependent Kinase Inhibitors"@en ;
  skos:narrower jvr:-GQSQKP48-C, jvr:-KH15TK52-L, jvr:-HWNZFD1D-5, jvr:-RB4M9P09-G, jvr:-RLFPS2G5-2, jvr:-T9S4F39R-C, jvr:-XC7R92L8-N ;
  mesh:allowableQualifier jvr:-XV06LPML-W, jvr:-NHL3D2X0-S, jvr:-T2TS0S41-N, jvr:-BT300B3G-Q, jvr:-CB30NGKB-3, jvr:-WK5F724J-1, jvr:-HQRFT0C6-B, jvr:-CJXMKG5Q-F, jvr:-Q3979798-W, jvr:-N2WP45CN-V, jvr:-THHNVC7V-3, jvr:-T9HQD7ST-J, jvr:-Z9TSGBXH-4, jvr:-G7KXQWSR-5, jvr:-W6SQV79N-S, jvr:-H7K65Q8S-Z, jvr:-NB0XHT3S-N, jvr:-WZF2ZR3L-B, jvr:-R0ZCQ8X6-J, jvr:-SBNWSM1T-R, jvr:-M63HSDM7-1, jvr:-G30ZJ446-J, jvr:-D0F21513-5, jvr:-S0CS1X5R-5, jvr:-R3QWLHRG-V, jvr:-NFTHND7Q-8, jvr:-NKM836P1-M, jvr:-TJHVZCRZ-0, jvr:-L6C0XPHT-4, jvr:-FWD2BGQ0-9 ;
  dc:created "2005-06-30"^^xsd:date ;
  skos:altLabel "Protéines inhibitrices des CDK"@fr, "Cyclin-Kinase Inhibitor Proteins"@en, "CDKI Proteins"@en, "Protéines inhibitrices des kinases dépendantes des cyclines"@fr, "Cyclin-kinase inhibitor"@fr, "Protéines CDKI"@fr, "CKI (Cyclin-Kinase Inhibitor)"@fr, "Protéines CKI"@fr, "CKI (Cyclin-dependent Kinase Inhibitor)"@fr, "Cyclin-dependent kinase inhibitor"@fr, "CKI Proteins"@en, "CDKI"@fr ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D050756> ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-JSW5590K-N, jvr:-LL18Q2Q5-H, jvr:-RZ7ZF59C-G ;
  dc:modified "2015-11-23"^^xsd:date ;
  skos:prefLabel "Protéines inhibitrices des kinases cyclines-dépendantes"@fr, "Cyclin-Dependent Kinase Inhibitor Proteins"@en ;
  dc:established "2006-01-01"^^xsd:date ;
  skos:inScheme jvr: ;
  mesh:pharmacologicalAction jvr:-KXZ6LKPS-T ;
  skos:definition "A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION. A family of cell cycle proteins containing ANKYRIN REPEATS that are specific inhibitors of cyclin D-dependent kinases. INK4 proteins bind to CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. They dissociate cyclin-CDK complexes and regulate a CELL CYCLE checkpoint in early G1 PHASE."@en .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9S4F39R-C
  skos:prefLabel "Cyclin-Dependent Kinase Inhibitor p18"@en, "Inhibiteur p18 de kinase cycline-dépendante"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-XC7R92L8-N
  skos:prefLabel "Cyclin-Dependent Kinase Inhibitor p19"@en, "Inhibiteur p19 de kinase cycline-dépendante"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-LL18Q2Q5-H
  skos:prefLabel "Protéines suppresseurs de tumeurs"@fr, "Tumor Suppressor Proteins"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-P5K3DBDP-J .

jvr:-RLFPS2G5-2
  skos:prefLabel "Cyclin-Dependent Kinase Inhibitor p15"@en, "Inhibiteur p15 de kinase cycline-dépendante"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HWNZFD1D-5
  skos:prefLabel "Inhibiteur p57 de kinase cycline-dépendante"@fr, "Cyclin-Dependent Kinase Inhibitor p57"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-KH15TK52-L
  skos:prefLabel "Cyclin-Dependent Kinase Inhibitor p27"@en, "Inhibiteur p27 de kinase cycline-dépendante"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-P5K3DBDP-J .

jvr:-KXZ6LKPS-T
  skos:prefLabel "Protein Kinase Inhibitors"@en, "Inhibiteurs de protéines kinases"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-RZ7ZF59C-G
  skos:prefLabel "Intracellular Signaling Peptides and Proteins"@en, "Protéines et peptides de signalisation intracellulaire"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-P5K3DBDP-J .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .