@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-N03X55QR-S
  skos:prefLabel "Acides picoliniques"@fr, "Picolinic Acids"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-NL12ZTWT-1 .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R6T8NP9F-T
  skos:prefLabel "Nucleic Acid Synthesis Inhibitors"@en, "Inhibiteurs de la synthèse d'acide nucléique"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-NL12ZTWT-1
  skos:definition "A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis."@en ;
  mesh:allowableQualifier jvr:-BT300B3G-Q, jvr:-THHNVC7V-3, jvr:-Q3979798-W, jvr:-CB30NGKB-3, jvr:-FWD2BGQ0-9, jvr:-L6C0XPHT-4, jvr:-R0ZCQ8X6-J, jvr:-G30ZJ446-J, jvr:-R3QWLHRG-V, jvr:-Z9TSGBXH-4, jvr:-NFTHND7Q-8, jvr:-G7KXQWSR-5, jvr:-TJHVZCRZ-0, jvr:-D0F21513-5, jvr:-SBNWSM1T-R, jvr:-T9HQD7ST-J, jvr:-H7K65Q8S-Z, jvr:-HQRFT0C6-B, jvr:-G4R176S9-J, jvr:-W6SQV79N-S, jvr:-S0CS1X5R-5, jvr:-NHL3D2X0-S, jvr:-M63HSDM7-1, jvr:-XV06LPML-W, jvr:-WK5F724J-1, jvr:-NKM836P1-M, jvr:-NB0XHT3S-N ;
  a mesh:Descriptor, skos:Concept ;
  dc:created "1974-11-19"^^xsd:date ;
  skos:prefLabel "Acide fusarique"@fr, "Fusaric Acid"@en ;
  skos:inScheme jvr: ;
  mesh:pharmacologicalAction jvr:-RNN9WKG8-L, jvr:-R6T8NP9F-T, jvr:-CW1BZZWB-6 ;
  skos:broader jvr:-N03X55QR-S ;
  dc:established "1991-01-01"^^xsd:date ;
  skos:hiddenLabel "Calcium Fusarate"@en, "Fusarate calcique"@fr, "Fusarate de calcium"@fr ;
  skos:altLabel "2-Pyridinecarboxylic acid, 5-butyl-"@fr, "2-Pyridinecarboxylic acid, 5-butyl-"@en, "5-Butyl-2-pyridinedicarboxylic Acid"@en, "536-69-6 (Fusaric Acid)"@en, "536-69-6 (Fusaric Acid)"@fr, "JWJ963070N"@fr, "JWJ963070N"@en ;
  dc:modified "2016-05-31"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D005669> .

jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CW1BZZWB-6
  skos:prefLabel "Agents dopaminergiques"@fr, "Dopamine Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-RNN9WKG8-L
  skos:prefLabel "Enzyme Inhibitors"@en, "Antienzymes"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .