@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-VTVNKZWP-B skos:prefLabel "Antinéoplasiques"@fr, "Antineoplastic Agents"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-N4305JHC-P . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-V4MM0TSX-M mesh:pharmacologicalAction jvr:-N4305JHC-P . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N4305JHC-P skos:altLabel "Médicaments cytotoxiques"@fr, "Agents cytotoxiques"@fr, "Cytotoxic Agent"@en, "Cytotoxic Agents"@en, "Cytotoxin"@en, "Substances cytotoxiques"@fr ; dc:created "1977-04-22"^^xsd:date ; skos:related jvr:-KXXBM52X-N, jvr:-VTVNKZWP-B ; skos:broader jvr:-S1JFLTH9-3 ; skos:definition "Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS."@en ; mesh:allowableQualifier jvr:-NHL3D2X0-S, jvr:-W6SQV79N-S, jvr:-S0CS1X5R-5, jvr:-BT300B3G-Q, jvr:-TJHVZCRZ-0, jvr:-R3QWLHRG-V, jvr:-NB0XHT3S-N, jvr:-WK5F724J-1, jvr:-HQRFT0C6-B, jvr:-M63HSDM7-1, jvr:-SBNWSM1T-R, jvr:-L6C0XPHT-4, jvr:-XV06LPML-W, jvr:-G7KXQWSR-5, jvr:-H7K65Q8S-Z, jvr:-CJXMKG5Q-F, jvr:-NKM836P1-M, jvr:-D0F21513-5, jvr:-CB30NGKB-3, jvr:-G30ZJ446-J, jvr:-T9HQD7ST-J, jvr:-FWD2BGQ0-9, jvr:-Q3979798-W, jvr:-NFTHND7Q-8, jvr:-Z9TSGBXH-4, jvr:-THHNVC7V-3, jvr:-R0ZCQ8X6-J, jvr:-WZF2ZR3L-B ; a skos:Concept, mesh:Descriptor ; owl:sameAs ; dc:modified "2021-06-30"^^xsd:date ; skos:prefLabel "Cytotoxines"@fr, "Cytotoxins"@en ; skos:hiddenLabel "Cytolysins"@en, "Cytolysines"@fr ; dc:established "1978-01-01"^^xsd:date ; skos:narrower jvr:-BRDDMX7L-V ; skos:inScheme jvr: . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-KXXBM52X-N skos:prefLabel "Cytostatic Agents"@en, "Cytostatiques"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-N4305JHC-P . jvr: a skos:ConceptScheme . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-ZZV7F98L-2 mesh:pharmacologicalAction jvr:-N4305JHC-P . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-K2D2S51P-0 mesh:pharmacologicalAction jvr:-N4305JHC-P . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-BRDDMX7L-V skos:prefLabel "Hémolytiques"@fr, "Hemolytic Agents"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-N4305JHC-P . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-F9M1X520-6 mesh:pharmacologicalAction jvr:-N4305JHC-P . jvr:-S1JFLTH9-3 skos:prefLabel "Noxas"@fr, "Noxae"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-N4305JHC-P . jvr:-PHRTKPP3-2 mesh:pharmacologicalAction jvr:-N4305JHC-P . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .