@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-MXRVP4BM-Z
  a skos:Concept, mesh:Descriptor ;
  mesh:allowableQualifier jvr:-FWD2BGQ0-9, jvr:-D0F21513-5, jvr:-G7KXQWSR-5, jvr:-H7K65Q8S-Z, jvr:-W6SQV79N-S, jvr:-HQRFT0C6-B, jvr:-WK5F724J-1, jvr:-CB30NGKB-3, jvr:-BT300B3G-Q, jvr:-NKM836P1-M, jvr:-N2WP45CN-V, jvr:-SBNWSM1T-R, jvr:-NB0XHT3S-N, jvr:-XV06LPML-W, jvr:-NFTHND7Q-8, jvr:-NHL3D2X0-S, jvr:-L6C0XPHT-4, jvr:-WZF2ZR3L-B, jvr:-TJHVZCRZ-0, jvr:-Z9TSGBXH-4, jvr:-G30ZJ446-J, jvr:-Q3979798-W, jvr:-T2TS0S41-N, jvr:-S0CS1X5R-5 ;
  skos:prefLabel "Denosumab"@en, "Dénosumab"@fr ;
  mesh:pharmacologicalAction jvr:-BBJDHV4W-1 ;
  skos:broader jvr:-NJHH5T6R-L ;
  skos:hiddenLabel "AMG 162"@fr, "AMG 162"@en, "Prolia"@fr, "Prolia"@en, "Xgeva"@fr, "Xgeva"@en ;
  skos:altLabel "4EQZ6YO2HI"@en, "4EQZ6YO2HI"@fr, "615258-40-7 (denosumab)"@fr, "615258-40-7 (denosumab)"@en ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000069448> ;
  dc:created "2015-07-01"^^xsd:date ;
  skos:related jvr:-FQ0M8ZXB-R ;
  dc:established "2016-01-01"^^xsd:date ;
  skos:definition "A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS."@en ;
  dc:modified "2017-06-20"^^xsd:date ;
  skos:inScheme jvr: .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NJHH5T6R-L
  skos:prefLabel "Anticorps monoclonaux humanisés"@fr, "Antibodies, Monoclonal, Humanized"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-MXRVP4BM-Z .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-BBJDHV4W-1
  skos:prefLabel "Bone Density Conservation Agents"@en, "Agents de maintien de la densité osseuse"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-FQ0M8ZXB-R
  skos:prefLabel "Ligand de RANK"@fr, "RANK Ligand"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-MXRVP4BM-Z .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .