@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-PPKJKFKK-V
  skos:prefLabel "ethics (Qualifier)"@en, "éthique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-FGT1KCV8-7
  skos:prefLabel "Complement Activation"@en, "Activation du complément"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-MSTCHM92-4 .

jvr: a skos:ConceptScheme .
jvr:-MSTCHM92-4
  skos:prefLabel "Voie classique d'activation du complément"@fr, "Complement Pathway, Classical"@en ;
  mesh:allowableQualifier jvr:-N2WP45CN-V, jvr:-S0CS1X5R-5, jvr:-PPKJKFKK-V, jvr:-H7K65Q8S-Z, jvr:-WZF2ZR3L-B, jvr:-Z9TSGBXH-4 ;
  skos:altLabel "Complement Activation Pathway, Classical"@en, "Classical Complement Activation Pathway"@en, "Voie classique du complément"@fr, "Classical Complement Pathway"@en ;
  dc:modified "2016-06-23"^^xsd:date ;
  skos:inScheme jvr: ;
  skos:broader jvr:-FGT1KCV8-7 ;
  a skos:Concept, mesh:Descriptor ;
  dc:established "1991-01-01"^^xsd:date ;
  skos:definition "Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX."@en ;
  dc:created "1977-12-02"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D003171> .