@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M5NWMH2L-0
  a mesh:Descriptor, skos:Concept ;
  skos:altLabel "Protéine-1 à domaine SAM et à domaine HD"@fr, "SAMHD1 dNTPase"@en, "SAMHD1 dNTPase"@fr, "Protéine SAMHD1"@fr, "SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase"@fr, "SAMHD1 Protein"@en, "SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase"@en, "Déoxynucléoside triphosphate triphosphohydrolase SAMHD1"@fr ;
  mesh:allowableQualifier jvr:-M63HSDM7-1, jvr:-S0CS1X5R-5, jvr:-WK5F724J-1, jvr:-NFTHND7Q-8, jvr:-G7KXQWSR-5, jvr:-Q3979798-W, jvr:-T9HQD7ST-J, jvr:-L6C0XPHT-4, jvr:-W6SQV79N-S, jvr:-H7K65Q8S-Z, jvr:-D0F21513-5, jvr:-XV06LPML-W, jvr:-T2TS0S41-N, jvr:-NB0XHT3S-N, jvr:-TJHVZCRZ-0, jvr:-CB30NGKB-3, jvr:-Z9TSGBXH-4, jvr:-WZF2ZR3L-B, jvr:-N2WP45CN-V, jvr:-HQRFT0C6-B, jvr:-NKM836P1-M, jvr:-BT300B3G-Q, jvr:-R3QWLHRG-V, jvr:-G30ZJ446-J, jvr:-THHNVC7V-3, jvr:-CJXMKG5Q-F, jvr:-NHL3D2X0-S, jvr:-SBNWSM1T-R, jvr:-FWD2BGQ0-9 ;
  dc:modified "2021-05-10"^^xsd:date ;
  skos:broader jvr:-JWR6C6ZR-C, jvr:-MT0Q4FC5-D, jvr:-QXQD6SR2-3 ;
  skos:prefLabel "Protéine-1 contenant un domaine SAM et un domaine HD"@fr, "SAM Domain and HD Domain-Containing Protein 1"@en ;
  skos:hiddenLabel "EC 3.6.-"@fr, "EC 3.6.-"@en, "EC 3.1.5.-"@fr, "EC 3.1.5.-"@en ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000076106> ;
  skos:definition "A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2)."@en ;
  mesh:registryNumber "EC 3.6.-", "EC 3.1.5.-" ;
  dc:created "2017-07-11"^^xsd:date ;
  skos:inScheme jvr: ;
  dc:established "2018-01-01"^^xsd:date .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-MT0Q4FC5-D
  skos:prefLabel "Antiviral Restriction Factors"@en, "Facteurs de restriction antiviraux"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-M5NWMH2L-0 .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-JWR6C6ZR-C
  skos:prefLabel "Ribonucléases"@fr, "Ribonucleases"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-M5NWMH2L-0 .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-QXQD6SR2-3
  skos:prefLabel "Acid anhydride hydrolases"@fr, "Acid Anhydride Hydrolases"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-M5NWMH2L-0 .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .