@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-LCHVRL34-H
  skos:prefLabel "Protein Precursors"@en, "Précurseurs de protéines"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-LWNTJNKQ-7 .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D8P8PZHP-H
  skos:prefLabel "Hémophilie A"@fr, "Hemophilia A"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-LWNTJNKQ-7 .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-XB7BBVD9-P
  skos:prefLabel "Facteur VIIIa"@fr, "Factor VIIIa"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-LWNTJNKQ-7 .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-LWNTJNKQ-7
  skos:hiddenLabel "Activité procoagulante du facteur VIII"@fr, "Facteur VIII coagulant"@fr, "Facteur VIIIc"@fr, "Factor VIII Coagulant Antigen"@en, "Hyate-C"@fr, "Hyate-C"@en, "Antigène coagulant du facteur VIII"@fr, "F VIII-C"@en, "Factor VIIIC"@en, "Factor VIII Procoagulant Activity"@en, "Antigène du facteur VIII coagulant"@fr, "Facteur VIII c"@fr, "Hyatt-C"@en, "Facteur VIIIC"@fr, "Factor VIII Clotting Antigen"@en, "Activité du facteur VIII procoagulant"@fr, "Factor 8 C"@en, "Facteur VIII C"@fr ;
  skos:altLabel "Thromboplastinogène"@fr, "Factor 8"@en, "Blood-coagulation factor VIII, complex"@fr, "Blood-coagulation factor VIII, complex"@en, "Facteur VIII de la coagulation"@fr, "Facteur anti-hémophilique A"@fr, "9001-27-8"@fr, "9001-27-8"@en, "Blood Coagulation Factor VIII"@en, "Thromboplastinogen"@en, "Factor Eight"@en, "Coagulation Factor VIII"@en, "Facteur antihémophilique A"@fr, "Facteur VIII de la coagulation sanguine"@fr ;
  mesh:pharmacologicalAction jvr:-SBHXTKJ4-2 ;
  mesh:allowableQualifier jvr:-NFTHND7Q-8, jvr:-Z9TSGBXH-4, jvr:-D0F21513-5, jvr:-SBNWSM1T-R, jvr:-WZF2ZR3L-B, jvr:-NB0XHT3S-N, jvr:-FWD2BGQ0-9, jvr:-T2TS0S41-N, jvr:-XV06LPML-W, jvr:-G30ZJ446-J, jvr:-H7K65Q8S-Z, jvr:-HQRFT0C6-B, jvr:-CB30NGKB-3, jvr:-THHNVC7V-3, jvr:-WK5F724J-1, jvr:-W6SQV79N-S, jvr:-R0ZCQ8X6-J, jvr:-NKM836P1-M, jvr:-G7KXQWSR-5, jvr:-Q3979798-W, jvr:-S0CS1X5R-5, jvr:-L6C0XPHT-4, jvr:-BT300B3G-Q, jvr:-M63HSDM7-1, jvr:-TJHVZCRZ-0, jvr:-R3QWLHRG-V, jvr:-N2WP45CN-V, jvr:-T9HQD7ST-J ;
  dc:established "1966-01-01"^^xsd:date ;
  skos:related jvr:-D8P8PZHP-H ;
  a mesh:Descriptor, skos:Concept ;
  skos:inScheme jvr: ;
  skos:broader jvr:-L31P524H-V, jvr:-LCHVRL34-H ;
  dc:modified "2019-05-30"^^xsd:date ;
  skos:definition "Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin."@en ;
  skos:prefLabel "Facteur VIII"@fr, "Factor VIII"@en ;
  skos:narrower jvr:-XB7BBVD9-P ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D005169> ;
  dc:created "1999-01-01"^^xsd:date .

jvr:-L31P524H-V
  skos:prefLabel "Facteurs de la coagulation sanguine"@fr, "Blood Coagulation Factors"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-LWNTJNKQ-7 .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-SBHXTKJ4-2
  skos:prefLabel "Coagulants"@fr, "Coagulants"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .