@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-N7KVT2HL-5
  skos:prefLabel "Inhibiteurs de l'angiogenèse"@fr, "Angiogenesis Inhibitors"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FN3PMDM5-6
  skos:prefLabel "Indoles"@fr, "Indoles"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-LH0SSM2F-J .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-VTVNKZWP-B
  skos:prefLabel "Antinéoplasiques"@fr, "Antineoplastic Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-LH0SSM2F-J
  mesh:pharmacologicalAction jvr:-VTVNKZWP-B, jvr:-N7KVT2HL-5, jvr:-KXZ6LKPS-T ;
  skos:broader jvr:-TBNH6R4S-F, jvr:-FN3PMDM5-6 ;
  dc:created "2018-07-09"^^xsd:date ;
  mesh:allowableQualifier jvr:-NB0XHT3S-N, jvr:-NFTHND7Q-8, jvr:-WK5F724J-1, jvr:-Q3979798-W, jvr:-FWD2BGQ0-9, jvr:-D0F21513-5, jvr:-H7K65Q8S-Z, jvr:-CB30NGKB-3, jvr:-W6SQV79N-S, jvr:-NHL3D2X0-S, jvr:-R0ZCQ8X6-J, jvr:-BT300B3G-Q, jvr:-HQRFT0C6-B, jvr:-L6C0XPHT-4, jvr:-THHNVC7V-3, jvr:-XV06LPML-W, jvr:-S0CS1X5R-5, jvr:-M63HSDM7-1, jvr:-SBNWSM1T-R, jvr:-T9HQD7ST-J, jvr:-TJHVZCRZ-0, jvr:-R3QWLHRG-V, jvr:-G30ZJ446-J, jvr:-NKM836P1-M, jvr:-G4R176S9-J ;
  skos:hiddenLabel "SU11248"@fr, "SU11248"@en, "SU 011248"@en, "SU 11248"@en, "SU011248"@fr, "SU011248"@en, "Sutent"@en, "Malate de sunitinib"@fr, "SU-11248"@fr, "SU-11248"@en, "SU-011248"@fr, "SU-011248"@en, "Sunitinib Malate"@en ;
  dc:established "2019-01-01"^^xsd:date ;
  skos:altLabel "LVX8N1UT73"@fr, "LVX8N1UT73"@en, "V99T50803M"@fr, "V99T50803M"@en, "5-(5-Fluoro-2-oxo-1,2-dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide"@en ;
  dc:modified "2019-04-29"^^xsd:date ;
  a mesh:Descriptor, skos:Concept ;
  skos:prefLabel "Sunitinib"@en, "Sunitinib"@fr ;
  skos:inScheme jvr: ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000077210> ;
  skos:definition "An indole and pyrrole derivative that inhibits VEGFR-2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA."@en .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-TBNH6R4S-F
  skos:prefLabel "Pyrroles"@fr, "Pyrroles"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-LH0SSM2F-J .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-KXZ6LKPS-T
  skos:prefLabel "Protein Kinase Inhibitors"@en, "Inhibiteurs de protéines kinases"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .