@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-KX7K4FRV-Z skos:altLabel "Guanine phosphoribosyltransférase"@fr, "Guanine Phosphoribosyltransferase"@en, "HPRTase"@en, "IMP pyrophosphorylase"@fr, "Hypoxanthine-Guanine Phosphoribosyltransferase"@en, "HGPRT"@en, "9016-12-0 (CAS RN)"@fr, "9016-12-0 (CAS RN)"@en, "HPRT"@en, "IMP:pyrophosphate phospho-D-ribosyltransferase"@fr, "IMP:pyrophosphate phospho-D-ribosyltransferase"@en, "IMP Pyrophosphorylase"@en ; mesh:allowableQualifier jvr:-Z9TSGBXH-4, jvr:-CJXMKG5Q-F, jvr:-W6SQV79N-S, jvr:-N2WP45CN-V, jvr:-FWD2BGQ0-9, jvr:-BT300B3G-Q, jvr:-S0CS1X5R-5, jvr:-HQRFT0C6-B, jvr:-D0F21513-5, jvr:-TJHVZCRZ-0, jvr:-G7KXQWSR-5, jvr:-T2TS0S41-N, jvr:-WK5F724J-1, jvr:-XV06LPML-W, jvr:-Q3979798-W, jvr:-NKM836P1-M, jvr:-G30ZJ446-J, jvr:-H7K65Q8S-Z, jvr:-M63HSDM7-1, jvr:-L6C0XPHT-4, jvr:-NFTHND7Q-8, jvr:-NB0XHT3S-N, jvr:-CB30NGKB-3, jvr:-WZF2ZR3L-B, jvr:-SBNWSM1T-R, jvr:-T9HQD7ST-J, jvr:-NHL3D2X0-S, jvr:-THHNVC7V-3, jvr:-R3QWLHRG-V ; skos:broader jvr:-NHZX9FSC-X ; mesh:registryNumber "EC 2.4.2.8" ; skos:prefLabel "Hypoxanthine Phosphoribosyltransferase"@en, "Hypoxanthine phosphoribosyltransferase"@fr ; dc:established "1975-09-01"^^xsd:date ; a mesh:Descriptor, skos:Concept ; owl:sameAs ; dc:created "1974-11-11"^^xsd:date ; skos:related jvr:-NRL7WKVS-9, jvr:-NNQ7D0W6-1 ; skos:inScheme jvr: ; skos:definition "An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8."@en ; dc:modified "2019-05-24"^^xsd:date ; skos:hiddenLabel "EC 2.4.2.8"@fr, "EC 2.4.2.8"@en . jvr:-NRL7WKVS-9 skos:prefLabel "Lesch-Nyhan Syndrome"@en, "Syndrome de Lesch-Nyhan"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-KX7K4FRV-Z . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NHZX9FSC-X skos:prefLabel "Pentosyltransferases"@fr, "Pentosyltransferases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-KX7K4FRV-Z . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NNQ7D0W6-1 skos:prefLabel "Gout"@en, "Goutte"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-KX7K4FRV-Z . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .