@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-BZBFZW0B-W skos:prefLabel "CRISPR-Associated Proteins"@en, "Protéines associées aux CRISPR"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-KQQKMSDB-X . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-MNNQWF81-4 skos:prefLabel "Gene Editing"@en, "Édition de gène"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-KQQKMSDB-X . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-RRFR8MKH-R skos:prefLabel "Bacterial Proteins"@en, "Protéines bactériennes"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-KQQKMSDB-X . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-MKBRFG3D-P skos:prefLabel "Endodeoxyribonucleases"@fr, "Endodeoxyribonucleases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-KQQKMSDB-X . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-ZS6JWWJB-L skos:prefLabel "Systèmes CRISPR-Cas"@fr, "CRISPR-Cas Systems"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-KQQKMSDB-X . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-KQQKMSDB-X mesh:allowableQualifier jvr:-NHL3D2X0-S, jvr:-L6C0XPHT-4, jvr:-R3QWLHRG-V, jvr:-XV06LPML-W, jvr:-WK5F724J-1, jvr:-H7K65Q8S-Z, jvr:-G30ZJ446-J, jvr:-W6SQV79N-S, jvr:-NB0XHT3S-N, jvr:-BT300B3G-Q, jvr:-G7KXQWSR-5, jvr:-Q3979798-W, jvr:-CJXMKG5Q-F, jvr:-CB30NGKB-3, jvr:-NFTHND7Q-8, jvr:-NKM836P1-M, jvr:-THHNVC7V-3, jvr:-T2TS0S41-N, jvr:-FWD2BGQ0-9, jvr:-TJHVZCRZ-0, jvr:-HQRFT0C6-B, jvr:-D0F21513-5, jvr:-Z9TSGBXH-4, jvr:-M63HSDM7-1, jvr:-N2WP45CN-V, jvr:-SBNWSM1T-R, jvr:-WZF2ZR3L-B, jvr:-S0CS1X5R-5, jvr:-T9HQD7ST-J ; skos:inScheme jvr: ; skos:altLabel "Cas9 Enzyme"@en, "Cas9 Protein"@en, "Cas9"@fr, "Protéine Cas9"@fr, "Endonucléase Cas9"@fr, "Cas9 Endonuclease"@en, "Enzyme Cas9"@fr ; owl:sameAs ; skos:related jvr:-ZS6JWWJB-L, jvr:-MNNQWF81-4 ; skos:hiddenLabel "EC 3.1.-"@fr, "EC 3.1.-"@en ; a skos:Concept, mesh:Descriptor ; skos:broader jvr:-RRFR8MKH-R, jvr:-BZBFZW0B-W, jvr:-MKBRFG3D-P ; dc:established "2019-01-01"^^xsd:date ; dc:modified "2021-07-07"^^xsd:date ; skos:definition "An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9."@en ; mesh:registryNumber "EC 3.1.-" ; skos:prefLabel "Protéine-9 associée à CRISPR"@fr, "CRISPR-Associated Protein 9"@en ; dc:created "2018-07-09"^^xsd:date . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .