@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q2367FVZ-J skos:prefLabel "Vibrio cholerae"@en, "Vibrio cholerae"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-K928J3KP-8 . jvr:-ZPM2NX43-6 skos:prefLabel "Toxiques"@fr, "Poisons"@en ; a mesh:Descriptor, skos:Concept . jvr:-K928J3KP-8 mesh:allowableQualifier jvr:-G7KXQWSR-5, jvr:-L6C0XPHT-4, jvr:-NB0XHT3S-N, jvr:-Q3979798-W, jvr:-WZF2ZR3L-B, jvr:-G30ZJ446-J, jvr:-BT300B3G-Q, jvr:-T9HQD7ST-J, jvr:-D0F21513-5, jvr:-WK5F724J-1, jvr:-NKM836P1-M, jvr:-CB30NGKB-3, jvr:-SBNWSM1T-R, jvr:-Z9TSGBXH-4, jvr:-S0CS1X5R-5, jvr:-NHL3D2X0-S, jvr:-XV06LPML-W, jvr:-NFTHND7Q-8, jvr:-HQRFT0C6-B, jvr:-R3QWLHRG-V, jvr:-THHNVC7V-3, jvr:-H7K65Q8S-Z, jvr:-R0ZCQ8X6-J, jvr:-FWD2BGQ0-9, jvr:-TJHVZCRZ-0, jvr:-W6SQV79N-S, jvr:-M63HSDM7-1 ; skos:altLabel "Entérotoxine cholérique"@fr, "Cholera Exotoxin"@en, "Choleragen"@en, "Cholera Enterotoxin CT"@en, "Choléragène"@fr, "Exotoxine cholérique"@fr, "9012-63-9"@fr, "9012-63-9"@en ; skos:prefLabel "Toxine cholérique"@fr, "Cholera Toxin"@en ; skos:hiddenLabel "Choléragénoïde"@fr, "Protomère B de la toxine cholérique"@fr, "Choleragenoid"@en, "Cholera Toxin Protomer A"@en, "Cholera Toxin A"@en, "Cholera Toxin Subunit B"@en, "Procholéragénoïde"@fr, "Cholera Toxin B Subunit"@en, "Cholera Toxin Protomer B"@en, "Cholera Toxin B"@en, "EC 2.4.2.31"@fr, "EC 2.4.2.31"@en, "Cholera Toxin A Subunit"@en, "Sous-unité A de la toxine cholérique"@fr, "Protomère A de la toxine cholérique"@fr, "Procholeragenoid"@en, "Sous-unité B de la toxine cholérique"@fr, "Cholera Toxin Subunit A"@en ; dc:created "1977-04-22"^^xsd:date ; skos:inScheme jvr: ; a skos:Concept, mesh:Descriptor ; skos:broader jvr:-ZQDSD9XK-P, jvr:-J72RJJQG-0, jvr:-HG5GSZL0-S ; dc:modified "2021-06-30"^^xsd:date ; mesh:pharmacologicalAction jvr:-ZPM2NX43-6, jvr:-Q3S6PSKC-B ; skos:definition "An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. The nontoxic, pentameric B protomer of cholera toxin. The cell membrane binding component of cholera toxin. Detoxified aggregate of cholera toxin formed by heat treatment of purified cholera toxin. The catalytic subunit of cholera toxin. It is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE."@en ; dc:established "1978-01-01"^^xsd:date ; skos:related jvr:-Q2367FVZ-J ; owl:sameAs ; mesh:registryNumber "EC 2.4.2.31" . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-HG5GSZL0-S skos:prefLabel "Entérotoxines"@fr, "Enterotoxins"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-K928J3KP-8 . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-J72RJJQG-0 skos:prefLabel "ADP Ribose Transferases"@en, "ADP ribose transferases"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-K928J3KP-8 . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-ZQDSD9XK-P skos:prefLabel "Bacterial Toxins"@en, "Toxines bactériennes"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-K928J3KP-8 . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q3S6PSKC-B skos:prefLabel "Adjuvants, Immunologic"@en, "Adjuvants immunologiques"@fr ; a mesh:Descriptor, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .