@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CQ2KMNMH-W skos:prefLabel "Piperidines"@en, "Pipéridines"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-K556171Q-V . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-TZFTN5TG-9 skos:prefLabel "Cannabinoid Receptor Antagonists"@en, "Antagonistes des récepteurs de cannabinoïdes"@fr ; a mesh:Descriptor, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-K556171Q-V mesh:allowableQualifier jvr:-BT300B3G-Q, jvr:-XV06LPML-W, jvr:-THHNVC7V-3, jvr:-NKM836P1-M, jvr:-W6SQV79N-S, jvr:-WK5F724J-1, jvr:-FWD2BGQ0-9, jvr:-R3QWLHRG-V, jvr:-TJHVZCRZ-0, jvr:-T9HQD7ST-J, jvr:-Q3979798-W, jvr:-G4R176S9-J, jvr:-D0F21513-5, jvr:-L6C0XPHT-4, jvr:-HQRFT0C6-B, jvr:-NHL3D2X0-S, jvr:-M63HSDM7-1, jvr:-G30ZJ446-J, jvr:-SBNWSM1T-R, jvr:-R0ZCQ8X6-J, jvr:-CB30NGKB-3, jvr:-NFTHND7Q-8, jvr:-NB0XHT3S-N, jvr:-S0CS1X5R-5, jvr:-H7K65Q8S-Z ; skos:hiddenLabel "SR141716A"@fr, "SR141716A"@en, "SR 141716A"@en, "SR-141716A"@fr, "SR-141716A"@en, "Chlorhydrate de rimonabant"@fr, "Rimonabant Hydrochloride"@en, "SR 141716"@en, "Zimulti"@en, "Acomplia"@en, "SR141716"@fr, "SR141716"@en, "SR-141716"@fr, "N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride"@en ; dc:modified "2018-02-27"^^xsd:date ; skos:altLabel "HL0V2LQZ09"@fr, "HL0V2LQZ09"@en, "158681-13-1 (Rimonabant)"@fr, "158681-13-1 (Rimonabant)"@en, "1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-"@en, "1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-"@fr, "RML78EN3XE"@fr, "RML78EN3XE"@en ; skos:prefLabel "Rimonabant"@fr, "Rimonabant"@en ; dc:established "2019-01-01"^^xsd:date ; a mesh:Descriptor, skos:Concept ; owl:sameAs ; mesh:pharmacologicalAction jvr:-TZFTN5TG-9, jvr:-LW94LSS1-H ; skos:definition "A pyrazole and piperidine derivative that acts as a selective cannabinoid type-1 receptor (CB1 RECEPTOR) antagonist. It inhibits the proliferation and maturation of ADIPOCYTES, improves lipid and glucose metabolism, and regulates food intake and energy balance. It is used in the management of OBESITY."@en ; skos:broader jvr:-GLDQPRZD-V, jvr:-CQ2KMNMH-W ; skos:inScheme jvr: ; dc:created "2018-07-09"^^xsd:date . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-GLDQPRZD-V skos:prefLabel "Pyrazoles"@en, "Pyrazoles"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-K556171Q-V . jvr:-LW94LSS1-H skos:prefLabel "Agents antiobésité"@fr, "Anti-Obesity Agents"@en ; a mesh:Descriptor, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G4R176S9-J skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .