@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-ZJBZVRWR-8
  skos:prefLabel "parasitologie (Qualificatif)"@fr, "parasitology (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-JTN1XC66-6
  mesh:allowableQualifier jvr:-T2TS0S41-N, jvr:-S0CS1X5R-5, jvr:-N2WP45CN-V, jvr:-ZJBZVRWR-8, jvr:-D0F21513-5, jvr:-VGWB97FS-5, jvr:-DH7H9MJ2-N, jvr:-L6C0XPHT-4, jvr:-P1X8SCQ6-K, jvr:-W6SQV79N-S, jvr:-T1QJHLQ4-J, jvr:-H7K65Q8S-Z, jvr:-WZF2ZR3L-B, jvr:-J9Z93VFN-9, jvr:-Z9TSGBXH-4 ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-SZC7WPZ1-H, jvr:-FMDSLPMV-N, jvr:-Q9ZX3ZGS-X ;
  skos:prefLabel "Neurofibrillary Tangles"@en, "Enchevêtrements neurofibrillaires"@fr ;
  skos:inScheme jvr: ;
  dc:created "1991-05-02"^^xsd:date ;
  skos:altLabel "Enchevêtrements de neurofibrilles"@fr ;
  dc:modified "2014-06-13"^^xsd:date ;
  skos:definition "Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease."@en ;
  skos:broader jvr:-JQNXNTV8-8 ;
  dc:established "1992-01-01"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D016874> .

jvr:-VGWB97FS-5
  skos:prefLabel "transplantation (Qualifier)"@en, "transplantation (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-JQNXNTV8-8
  skos:prefLabel "Neurofibrils"@en, "Neurofibrilles"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-JTN1XC66-6 .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-DH7H9MJ2-N
  skos:prefLabel "anatomopathologie (Qualificatif)"@fr, "pathology (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-T1QJHLQ4-J
  skos:prefLabel "microbiology (Qualifier)"@en, "microbiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-SZC7WPZ1-H
  skos:prefLabel "Tauopathies"@fr, "Tauopathies"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-JTN1XC66-6 .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q9ZX3ZGS-X
  skos:prefLabel "Protéines neurofilamenteuses"@fr, "Neurofilament Proteins"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-JTN1XC66-6 .

jvr:-J9Z93VFN-9
  skos:prefLabel "enzymology (Qualifier)"@en, "enzymologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-P1X8SCQ6-K
  skos:prefLabel "virologie (Qualificatif)"@fr, "virology (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-FMDSLPMV-N
  skos:prefLabel "Maladie de Kosaka-Shibayama"@fr, "Diffuse Neurofibrillary Tangles with Calcification"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-JTN1XC66-6 .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .