@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-JS1888SW-1
  mesh:allowableQualifier jvr:-SBNWSM1T-R, jvr:-FWD2BGQ0-9, jvr:-WK5F724J-1, jvr:-NHL3D2X0-S, jvr:-H7K65Q8S-Z, jvr:-W6SQV79N-S, jvr:-TJHVZCRZ-0, jvr:-NKM836P1-M, jvr:-THHNVC7V-3, jvr:-XV06LPML-W, jvr:-HQRFT0C6-B, jvr:-S0CS1X5R-5, jvr:-D0F21513-5, jvr:-T9HQD7ST-J, jvr:-Q3979798-W, jvr:-R3QWLHRG-V, jvr:-NFTHND7Q-8, jvr:-BT300B3G-Q, jvr:-G30ZJ446-J, jvr:-M63HSDM7-1, jvr:-NB0XHT3S-N, jvr:-WZF2ZR3L-B, jvr:-L6C0XPHT-4, jvr:-CB30NGKB-3, jvr:-G4R176S9-J, jvr:-R0ZCQ8X6-J ;
  skos:hiddenLabel "Retin-A"@en, "Trétinoïne potassique"@fr, "Trétinoïne de zinc"@fr, "Trétinoïne de sodium"@fr, "Acide rétinoïque bêta tout trans"@fr, "Tretinoin Zinc Salt"@en, "Tretinoin Sodium Salt"@en, "beta-all-trans-Retinoic Acid"@en, "Acide tout trans rétinoïque bêta"@fr, "Trétinoïne zincique"@fr, "Vesanoid"@en, "Tretinoin Potassium Salt"@en, "Trétinoïne de potassium"@fr, "Trétinoïne sodique"@fr ;
  skos:related jvr:-R6JQTJ7S-3 ;
  skos:altLabel "all-trans-Retinoic Acid"@en, "Vitamin A Acid"@en, "22232-80-0 (K salt)"@fr, "22232-80-0 (K salt)"@en, "Retinoic acid"@fr, "Retinoic acid"@en, "Vitamine A acide"@fr, "Acide rétinoïque tout trans"@fr, "trans-Retinoic Acid"@en, "Acide tout trans rétinoïque"@fr, "5688UTC01R"@fr, "5688UTC01R"@en, "75980-27-7 (Zn salt)"@fr, "75980-27-7 (Zn salt)"@en, "Retinoic Acid"@en, "13497-05-7 (Na salt)"@fr, "13497-05-7 (Na salt)"@en, "302-79-4 (Tretinoin)"@fr, "302-79-4 (Tretinoin)"@en ;
  mesh:pharmacologicalAction jvr:-VTVNKZWP-B, jvr:-M2SMNF4X-1 ;
  skos:inScheme jvr: ;
  dc:established "1980-01-01"^^xsd:date ;
  a mesh:Descriptor, skos:Concept ;
  dc:modified "2020-06-09"^^xsd:date ;
  skos:definition "An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE)."@en ;
  skos:narrower jvr:-KFJ4D39G-0 ;
  skos:prefLabel "Tretinoin"@en, "Trétinoïne"@fr ;
  skos:broader jvr:-J1H5HV4T-2 ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D014212> ;
  dc:created "1974-11-11"^^xsd:date .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-KFJ4D39G-0
  skos:prefLabel "Alitretinoin"@en, "Alitrétinoïne"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-JS1888SW-1 .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-VTVNKZWP-B
  skos:prefLabel "Antinéoplasiques"@fr, "Antineoplastic Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-J1H5HV4T-2
  skos:prefLabel "Rétinol"@fr, "Vitamin A"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-JS1888SW-1 .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R6JQTJ7S-3
  skos:prefLabel "Receptors, Retinoic Acid"@en, "Récepteurs à l'acide rétinoïque"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-JS1888SW-1 .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M2SMNF4X-1
  skos:prefLabel "Kératolytiques"@fr, "Keratolytic Agents"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .