@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-MTJDR7DH-J mesh:pharmacologicalAction jvr:-J57SG0C2-6 .
jvr:-HGD6GZ6P-K
  skos:prefLabel "Antihistaminiques des récepteurs H1"@fr, "Histamine H1 Antagonists"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-J57SG0C2-6 .

jvr:-PFLXXSV3-F
  skos:prefLabel "Anti-Allergic Agents"@en, "Antiallergiques"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-J57SG0C2-6 .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-J57SG0C2-6
  mesh:allowableQualifier jvr:-NB0XHT3S-N, jvr:-NKM836P1-M, jvr:-W6SQV79N-S, jvr:-TJHVZCRZ-0, jvr:-THHNVC7V-3, jvr:-SBNWSM1T-R, jvr:-Q3979798-W, jvr:-CB30NGKB-3, jvr:-S0CS1X5R-5, jvr:-XV06LPML-W, jvr:-HQRFT0C6-B, jvr:-BT300B3G-Q, jvr:-R3QWLHRG-V, jvr:-FWD2BGQ0-9, jvr:-L6C0XPHT-4, jvr:-G30ZJ446-J, jvr:-T9HQD7ST-J, jvr:-D0F21513-5, jvr:-WK5F724J-1, jvr:-H7K65Q8S-Z, jvr:-NFTHND7Q-8, jvr:-NHL3D2X0-S ;
  dc:created "2002-07-02"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D039563> ;
  skos:hiddenLabel "Third Generation H1 Antagonists"@en, "Antihistaminiques H1 de troisième génération"@fr, "Third Generation H1 Antagonist"@en, "Anti-histaminiques de troisième génération non sédatifs"@fr, "Antihistaminiques de troisième génération non sédatifs"@fr, "Antihistaminiques de troisième génération"@fr ;
  skos:prefLabel "Antihistaminiques H1 non sédatifs"@fr, "Histamine H1 Antagonists, Non-Sedating"@en ;
  skos:altLabel "Antihistaminiques de seconde génération"@fr, "Antagonistes de l'histamine H1 non sédatifs"@fr, "Anti-histaminiques H1 non sédatifs"@fr, "H1 Antihistamines, Non-Sedating"@en, "Second Generation H1 Antagonists"@en, "Second Generation Antihistamines"@en, "Anti-histaminiques de seconde génération"@fr, "Second Generation Antihistamine"@en, "Second Generation H1 Antagonist"@en ;
  a skos:Concept, mesh:Descriptor ;
  skos:broader jvr:-HGD6GZ6P-K ;
  skos:inScheme jvr: ;
  dc:established "2003-01-01"^^xsd:date ;
  dc:modified "2020-05-27"^^xsd:date ;
  skos:related jvr:-PFLXXSV3-F ;
  skos:definition "A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. Active enantiomers and selective derivatives of second generation H1 antagonists."@en .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XHVMZVPD-6 mesh:pharmacologicalAction jvr:-J57SG0C2-6 .
jvr:-X6F4GVW4-2 mesh:pharmacologicalAction jvr:-J57SG0C2-6 .
jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-DP9CHKKL-T mesh:pharmacologicalAction jvr:-J57SG0C2-6 .
jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TS3KTFJG-7 mesh:pharmacologicalAction jvr:-J57SG0C2-6 .
jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .