@prefix jvr: . @prefix mesh: . @prefix skos: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-QK3B2N94-0 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-D9TMLPNK-F skos:prefLabel "Hypersensitivity, Immediate"@en, "Hypersensibilité immédiate"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-HGD6GZ6P-K . jvr:-CLS34K58-Q mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-GXZ86F6D-H mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-R7RKLC7D-T mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-GVVC266B-V mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-RWKPV2DK-4 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-L4D1QCGV-8 skos:prefLabel "Hypnotics and Sedatives"@en, "Hypnotiques et sédatifs"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-HGD6GZ6P-K . jvr:-HGD6GZ6P-K skos:hiddenLabel "Antihistaminiques classiques"@fr, "Antihistamines, Classical"@en, "Antihistaminics, Classical"@en, "Antihistamines, Sedating"@en, "Antihistaminiques de première génération"@fr, "First Generation H1 Antagonists"@en ; mesh:allowableQualifier jvr:-NFTHND7Q-8, jvr:-D0F21513-5, jvr:-SBNWSM1T-R, jvr:-G30ZJ446-J, jvr:-CB30NGKB-3, jvr:-NKM836P1-M, jvr:-FWD2BGQ0-9, jvr:-NHL3D2X0-S, jvr:-H7K65Q8S-Z, jvr:-R3QWLHRG-V, jvr:-S0CS1X5R-5, jvr:-Q3979798-W, jvr:-TJHVZCRZ-0, jvr:-W6SQV79N-S, jvr:-XV06LPML-W, jvr:-NB0XHT3S-N, jvr:-BT300B3G-Q, jvr:-L6C0XPHT-4, jvr:-T9HQD7ST-J, jvr:-THHNVC7V-3, jvr:-WK5F724J-1, jvr:-HQRFT0C6-B ; skos:narrower jvr:-J57SG0C2-6 ; skos:inScheme jvr: ; skos:altLabel "Histamine H1 Antagonist"@en, "Histamine H1 Receptor Blockaders"@en, "Antihistaminics, H1"@en, "Antagonistes des récepteurs histaminergiques H1"@fr, "Antagonistes H1"@fr, "Antihistamines H1"@fr, "Histamine H1 Receptor Antagonist"@en, "Receptor Blockaders, H1"@en, "Antihistaminiques H1"@fr, "Histamine H1 Receptor Antagonists"@en, "H1 Receptor Blockaders"@en, "Histamine H1 Blockers"@en, "Blockaders, Histamine H1 Receptor"@en, "Anti-histaminiques H1"@fr, "Anti-histamines H1"@fr, "Antagonists, Histamine H1"@en, "Antagonists, Histamine H1 Receptor"@en ; skos:related jvr:-L4D1QCGV-8, jvr:-D9TMLPNK-F, jvr:-PFLXXSV3-F, jvr:-KD3ZGZ4K-4 ; dc:created "1976-05-05"^^xsd:date ; skos:prefLabel "Antihistaminiques des récepteurs H1"@fr, "Histamine H1 Antagonists"@en ; skos:definition "Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood."@en ; dc:established "1977-01-01"^^xsd:date ; a mesh:Descriptor, skos:Concept ; dc:modified "2021-06-30"^^xsd:date ; owl:sameAs ; skos:broader jvr:-PVLL6K0M-3 . jvr:-Q26GDFMB-1 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-C0J0CKB8-N mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-ZLQ16WT4-S mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R73SG74N-Q mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-WTN9W3D6-8 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-GNHZKJQG-2 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-SSGR0B9D-5 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr: a skos:ConceptScheme . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-PFLXXSV3-F skos:prefLabel "Anti-Allergic Agents"@en, "Antiallergiques"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-HGD6GZ6P-K . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-DBG587R2-R mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-KGXRH1R8-K mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S6W17HDK-J mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H5NMPJQW-D mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-PVLL6K0M-3 skos:prefLabel "Antihistaminiques"@fr, "Histamine Antagonists"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-HGD6GZ6P-K . jvr:-KD3ZGZ4K-4 skos:prefLabel "Bronchodilator Agents"@en, "Bronchodilatateurs"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-HGD6GZ6P-K . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-K576HN38-Q mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XMQZKGSP-3 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-PXLZH181-2 mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-MC45LQKR-X mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-V4LQV92H-G mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-PVQ07QMJ-W mesh:pharmacologicalAction jvr:-HGD6GZ6P-K . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-J57SG0C2-6 skos:prefLabel "Histamine H1 Antagonists, Non-Sedating"@en, "Antihistaminiques H1 non sédatifs"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-HGD6GZ6P-K . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .