@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-XD1F4DRZ-Q skos:prefLabel "Syndrome lymphoprolifératif avec auto-immunité"@fr, "Autoimmune Lymphoproliferative Syndrome"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-GR22J6Q7-B . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-GR22J6Q7-B skos:altLabel "Caspase-8"@fr, "Caspase-8"@en, "CAP4 Protease"@fr, "CAP4 Protease"@en, "Protéine FLICE"@fr, "Mch5 Protease"@en, "Mch5 protease"@fr, "FLICE Protein"@en, "MACH Protein"@en, "Protéine MACH"@fr ; skos:hiddenLabel "Pro-Caspase 8"@fr, "Procaspase-8"@fr, "Procaspase-8"@en, "EC 3.4.22.-"@fr, "EC 3.4.22.-"@en, "Pro-Caspase-8"@fr, "Pro-Caspase-8"@en, "Procaspase 8"@fr ; mesh:allowableQualifier jvr:-W6SQV79N-S, jvr:-H7K65Q8S-Z, jvr:-NFTHND7Q-8, jvr:-FWD2BGQ0-9, jvr:-WK5F724J-1, jvr:-XV06LPML-W, jvr:-Q3979798-W, jvr:-NHL3D2X0-S, jvr:-D0F21513-5, jvr:-L6C0XPHT-4, jvr:-T2TS0S41-N, jvr:-WZF2ZR3L-B, jvr:-Z9TSGBXH-4, jvr:-NB0XHT3S-N, jvr:-THHNVC7V-3, jvr:-TJHVZCRZ-0, jvr:-G30ZJ446-J, jvr:-S0CS1X5R-5, jvr:-CB30NGKB-3, jvr:-G7KXQWSR-5, jvr:-HQRFT0C6-B, jvr:-R3QWLHRG-V, jvr:-N2WP45CN-V, jvr:-SBNWSM1T-R, jvr:-T9HQD7ST-J, jvr:-NKM836P1-M, jvr:-BT300B3G-Q ; a skos:Concept, mesh:Descriptor ; owl:sameAs ; dc:modified "2021-06-28"^^xsd:date ; skos:definition "A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS."@en ; skos:broader jvr:-KGHHM5B2-1, jvr:-B8KSSJCV-G ; mesh:registryNumber "EC 3.4.22.-" ; skos:related jvr:-XD1F4DRZ-Q ; dc:established "2007-01-01"^^xsd:date ; skos:inScheme jvr: ; dc:created "2006-07-05"^^xsd:date ; skos:prefLabel "Caspase 8"@en, "Caspase 8"@fr . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-B8KSSJCV-G skos:prefLabel "Caspases initiatrices"@fr, "Caspases, Initiator"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-GR22J6Q7-B . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-KGHHM5B2-1 skos:prefLabel "Protéines adaptatrices de signalisation des récepteurs à domaine de mort"@fr, "Death Domain Receptor Signaling Adaptor Proteins"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-GR22J6Q7-B . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .