@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H223424B-W skos:prefLabel "Steroid hydroxylases"@fr, "Steroid Hydroxylases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-F1J1QCL5-M . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-F1J1QCL5-M mesh:allowableQualifier jvr:-S0CS1X5R-5, jvr:-BT300B3G-Q, jvr:-M63HSDM7-1, jvr:-G30ZJ446-J, jvr:-NB0XHT3S-N, jvr:-WZF2ZR3L-B, jvr:-SBNWSM1T-R, jvr:-R3QWLHRG-V, jvr:-HQRFT0C6-B, jvr:-XV06LPML-W, jvr:-G7KXQWSR-5, jvr:-WK5F724J-1, jvr:-Z9TSGBXH-4, jvr:-T9HQD7ST-J, jvr:-THHNVC7V-3, jvr:-TJHVZCRZ-0, jvr:-T2TS0S41-N, jvr:-N2WP45CN-V, jvr:-NHL3D2X0-S, jvr:-CJXMKG5Q-F, jvr:-FWD2BGQ0-9, jvr:-Q3979798-W, jvr:-CB30NGKB-3, jvr:-L6C0XPHT-4, jvr:-NFTHND7Q-8, jvr:-W6SQV79N-S, jvr:-H7K65Q8S-Z, jvr:-NKM836P1-M, jvr:-D0F21513-5 ; skos:broader jvr:-H223424B-W, jvr:-CZDH7T87-D ; skos:altLabel "25-Hydroxycholécalciférol 1-hydroxylase"@fr, "25-Hydroxycholecalciferol 1-Hydroxylase"@en, "25-Hydroxyvitamin D 1-alpha-Hydroxylase"@en, "25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase"@en, "25-Hydroxycholecalciferol-1-Hydroxylase"@en, "Calcidiol 1-Monooxygénase"@fr, "CYP27B1"@fr, "CYP27B1"@en, "Cytochrome P450 27B1"@fr, "Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)"@fr, "Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)"@en, "Cytochrome P-450 CYP27B1"@fr, "Cytochrome P-450 CYP27B1"@en, "25-Hydroxyvitamin D2 1-hydroxylase"@en, "25-Hydroxyergocalciferol 1-alpha-Hydroxylase"@en, "Calcidiol 1-Monooxygenase"@en, "CYP 27B1"@fr ; skos:prefLabel "25-Hydroxyvitamin D3 1-alpha-Hydroxylase"@en, "25-Hydroxyvitamine D3 1-alpha-hydroxylase"@fr ; dc:modified "2019-04-29"^^xsd:date ; a skos:Concept, mesh:Descriptor ; skos:definition "A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol)."@en ; owl:sameAs ; dc:established "1991-01-01"^^xsd:date ; dc:created "1974-11-19"^^xsd:date ; mesh:registryNumber "EC 1.14.15.18" ; skos:inScheme jvr: ; skos:hiddenLabel "EC 1.14.15.18"@fr, "EC 1.14.15.18"@en . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CZDH7T87-D skos:prefLabel "Famille-27 de cytochromes P450"@fr, "Cytochrome P450 Family 27"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-F1J1QCL5-M . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .