@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-X01PHNZ0-3
  skos:prefLabel "Dérivés du biphényle"@fr, "Biphenyl Compounds"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-DXTRW5NZ-Q .

jvr:-FG8LP9J8-Q
  skos:prefLabel "Antihypertensive Agents"@en, "Antihypertenseurs"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-DXTRW5NZ-Q
  mesh:allowableQualifier jvr:-NHL3D2X0-S, jvr:-XV06LPML-W, jvr:-L6C0XPHT-4, jvr:-S0CS1X5R-5, jvr:-R0ZCQ8X6-J, jvr:-W6SQV79N-S, jvr:-NFTHND7Q-8, jvr:-FWD2BGQ0-9, jvr:-TJHVZCRZ-0, jvr:-M63HSDM7-1, jvr:-THHNVC7V-3, jvr:-HQRFT0C6-B, jvr:-Q3979798-W, jvr:-BT300B3G-Q, jvr:-R3QWLHRG-V, jvr:-G30ZJ446-J, jvr:-H7K65Q8S-Z, jvr:-D0F21513-5, jvr:-WK5F724J-1, jvr:-NKM836P1-M, jvr:-G4R176S9-J, jvr:-T9HQD7ST-J, jvr:-NB0XHT3S-N, jvr:-SBNWSM1T-R, jvr:-CB30NGKB-3 ;
  skos:altLabel "1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-"@en, "1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-"@fr, "J0E2756Z7N"@fr, "J0E2756Z7N"@en, "138402-11-6 (Irbesartan)"@en, "138402-11-6 (Irbesartan)"@fr ;
  dc:modified "2018-02-27"^^xsd:date ;
  dc:established "2019-01-01"^^xsd:date ;
  skos:hiddenLabel "Aprovel"@en, "BMS-186295"@fr, "BMS-186295"@en, "SR 47436"@en, "2-N-Butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one"@en, "BMS 186295"@en, "SR-47436"@fr, "SR-47436"@en, "Avapro"@en, "Karvea"@en ;
  skos:prefLabel "Irbesartan"@en, "Irbésartan"@fr ;
  mesh:pharmacologicalAction jvr:-GZMVXVQG-H, jvr:-FG8LP9J8-Q ;
  skos:broader jvr:-JBCQC8CJ-H, jvr:-BJD28743-B, jvr:-X01PHNZ0-3 ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000077405> ;
  skos:definition "A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease."@en ;
  a mesh:Descriptor, skos:Concept ;
  dc:created "2018-07-09"^^xsd:date ;
  skos:inScheme jvr: .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-GZMVXVQG-H
  skos:prefLabel "Antagonistes du récepteur de type 1 de l'angiotensine-II"@fr, "Angiotensin II Type 1 Receptor Blockers"@en ;
  a mesh:Descriptor, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-BJD28743-B
  skos:prefLabel "Tétrazoles"@fr, "Tetrazoles"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-DXTRW5NZ-Q .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-JBCQC8CJ-H
  skos:prefLabel "Spiro Compounds"@en, "Spiranes"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-DXTRW5NZ-Q .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .