@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-D7B4LCNR-D skos:prefLabel "Anticholesteremic Agents"@en, "Anticholestérolémiants"@fr ; a mesh:Descriptor, skos:Concept . jvr:-BZNZHQJL-K skos:prefLabel "Lovastatin"@en, "Lovastatine"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-D9FD2HPW-B . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Q6JNMX77-N skos:prefLabel "Hydroxymethylglutaryl-CoA Reductase Inhibitors"@en, "Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase"@fr ; a mesh:Descriptor, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-SL2ZV4P9-H skos:prefLabel "Hypolipidemic Agents"@en, "Hypolipémiants"@fr ; a mesh:Descriptor, skos:Concept . jvr:-KNG8JMH9-Q skos:prefLabel "Rosuvastatine de calcium"@fr, "Rosuvastatin Calcium"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-D9FD2HPW-B . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G4R176S9-J skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D9FD2HPW-B skos:altLabel "79902-63-9 (Simvastatin)"@fr, "79902-63-9 (Simvastatin)"@en, "AGG2FN16EV"@fr, "AGG2FN16EV"@en ; mesh:allowableQualifier jvr:-R3QWLHRG-V, jvr:-THHNVC7V-3, jvr:-CB30NGKB-3, jvr:-D0F21513-5, jvr:-NHL3D2X0-S, jvr:-L6C0XPHT-4, jvr:-HQRFT0C6-B, jvr:-M63HSDM7-1, jvr:-G4R176S9-J, jvr:-NKM836P1-M, jvr:-FWD2BGQ0-9, jvr:-S0CS1X5R-5, jvr:-T9HQD7ST-J, jvr:-Q3979798-W, jvr:-R0ZCQ8X6-J, jvr:-TJHVZCRZ-0, jvr:-NB0XHT3S-N, jvr:-NFTHND7Q-8, jvr:-BT300B3G-Q, jvr:-WK5F724J-1, jvr:-SBNWSM1T-R, jvr:-G30ZJ446-J, jvr:-W6SQV79N-S, jvr:-H7K65Q8S-Z, jvr:-XV06LPML-W ; skos:inScheme jvr: ; a skos:Concept, mesh:Descriptor ; skos:narrower jvr:-P5RKHMC8-L ; skos:hiddenLabel "Zocor"@en, "MK733"@fr, "Synvinolin"@en, "MK-733"@fr, "MK-733"@en ; owl:sameAs ; mesh:pharmacologicalAction jvr:-D7B4LCNR-D, jvr:-SL2ZV4P9-H, jvr:-Q6JNMX77-N ; skos:related jvr:-KNG8JMH9-Q ; dc:created "1997-06-20"^^xsd:date ; dc:modified "2017-01-17"^^xsd:date ; skos:definition "A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL."@en ; dc:established "1998-01-01"^^xsd:date ; skos:prefLabel "Simvastatine"@fr, "Simvastatin"@en ; skos:broader jvr:-BZNZHQJL-K . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-P5RKHMC8-L skos:prefLabel "Ezetimibe, Simvastatin Drug Combination"@en, "Association d'ézétimibe et de simvastatine"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-D9FD2HPW-B .