@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-FG8LP9J8-Q
  skos:prefLabel "Antihypertensive Agents"@en, "Antihypertenseurs"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWBNGBWP-4
  skos:prefLabel "Pyrimidines"@fr, "Pyrimidines"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-D6B6XXQ4-2 .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-R0ZCQ8X6-J
  skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-FX0XB7SZ-F
  skos:prefLabel "Sulfonamides"@fr, "Sulfonamides"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-D6B6XXQ4-2 .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D6B6XXQ4-2
  mesh:allowableQualifier jvr:-CB30NGKB-3, jvr:-G4R176S9-J, jvr:-L6C0XPHT-4, jvr:-NFTHND7Q-8, jvr:-XV06LPML-W, jvr:-D0F21513-5, jvr:-T9HQD7ST-J, jvr:-Q3979798-W, jvr:-NHL3D2X0-S, jvr:-G30ZJ446-J, jvr:-R3QWLHRG-V, jvr:-TJHVZCRZ-0, jvr:-WK5F724J-1, jvr:-NB0XHT3S-N, jvr:-NKM836P1-M, jvr:-H7K65Q8S-Z, jvr:-R0ZCQ8X6-J, jvr:-SBNWSM1T-R, jvr:-HQRFT0C6-B, jvr:-THHNVC7V-3, jvr:-W6SQV79N-S, jvr:-S0CS1X5R-5, jvr:-M63HSDM7-1, jvr:-FWD2BGQ0-9, jvr:-BT300B3G-Q ;
  skos:hiddenLabel "Ro-47-0203"@fr, "Ro-47-0203"@en, "Bosentan anhydre"@fr, "Tracleer"@en, "Ro 47-0203"@en, "Bosentan Monohydrate"@en, "Bosentan monohydraté"@fr, "Bosentan Anhydrous"@en ;
  skos:prefLabel "Bosentan"@en, "Bosentan"@fr ;
  skos:broader jvr:-FWBNGBWP-4, jvr:-FX0XB7SZ-F ;
  dc:modified "2018-02-27"^^xsd:date ;
  mesh:pharmacologicalAction jvr:-NL2ZZD6Z-9, jvr:-FG8LP9J8-Q ;
  skos:altLabel "Q326023R30"@fr, "Q326023R30"@en, "147536-97-8 (Bosentan)"@fr, "147536-97-8 (Bosentan)"@en, "XUL93R30K2"@fr, "XUL93R30K2"@en, "Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-"@en, "Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-"@fr, "4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide"@en ;
  skos:definition "A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS."@en ;
  dc:established "2019-01-01"^^xsd:date ;
  a mesh:Descriptor, skos:Concept ;
  skos:inScheme jvr: ;
  dc:created "2018-07-09"^^xsd:date ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D000077300> .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-G4R176S9-J
  skos:prefLabel "analogs & derivatives (Qualifier)"@en, "analogues et dérivés (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NL2ZZD6Z-9
  skos:prefLabel "Endothelin Receptor Antagonists"@en, "Antagonistes des récepteurs de l'endothéline"@fr ;
  a mesh:Descriptor, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .