@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix owl: . @prefix dc: . @prefix xsd: . jvr:-LCC3R1NK-2 skos:prefLabel "MAP Kinase Kinase Kinase 1"@fr, "MAP Kinase Kinase Kinase 1"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-Z5SSJH3B-X skos:prefLabel "MAP Kinase Kinase Kinase 3"@fr, "MAP Kinase Kinase Kinase 3"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-L4QZZ7C8-V skos:prefLabel "MAP Kinase Kinase Kinase 4"@fr, "MAP Kinase Kinase Kinase 4"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-X2T8VHD3-K skos:prefLabel "MAP Kinase Signaling System"@en, "Système de signalisation des MAP kinases"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-CS56KQ6Q-R . jvr:-TP5B7P0H-F skos:prefLabel "Protein Serine-Threonine Kinases"@en, "Protein-Serine-Threonine Kinases"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-CS56KQ6Q-R . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D8ZVB6VQ-3 skos:prefLabel "MAP Kinase Kinase Kinase 5"@fr, "MAP Kinase Kinase Kinase 5"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-XCZ8X8WJ-G skos:prefLabel "Protéines proto-oncogènes c-mos"@fr, "Proto-Oncogene Proteins c-mos"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NQZZPLM7-9 skos:prefLabel "raf Kinases"@en, "Kinases raf"@fr ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CS56KQ6Q-R mesh:allowableQualifier jvr:-BT300B3G-Q, jvr:-FWD2BGQ0-9, jvr:-NHL3D2X0-S, jvr:-D0F21513-5, jvr:-T9HQD7ST-J, jvr:-M63HSDM7-1, jvr:-Q3979798-W, jvr:-SBNWSM1T-R, jvr:-NKM836P1-M, jvr:-S0CS1X5R-5, jvr:-WZF2ZR3L-B, jvr:-CB30NGKB-3, jvr:-THHNVC7V-3, jvr:-W6SQV79N-S, jvr:-L6C0XPHT-4, jvr:-H7K65Q8S-Z, jvr:-N2WP45CN-V, jvr:-NB0XHT3S-N, jvr:-T2TS0S41-N, jvr:-XV06LPML-W, jvr:-Z9TSGBXH-4, jvr:-NFTHND7Q-8, jvr:-WK5F724J-1, jvr:-TJHVZCRZ-0, jvr:-G30ZJ446-J, jvr:-CJXMKG5Q-F, jvr:-R3QWLHRG-V, jvr:-HQRFT0C6-B, jvr:-G7KXQWSR-5 ; skos:narrower jvr:-NS81BFZ3-1, jvr:-XCZ8X8WJ-G, jvr:-D8ZVB6VQ-3, jvr:-Z5SSJH3B-X, jvr:-NQZZPLM7-9, jvr:-LCC3R1NK-2, jvr:-L4QZZ7C8-V ; skos:prefLabel "MAP Kinase Kinase Kinases"@en, "MAP Kinase Kinase Kinases"@fr ; skos:hiddenLabel "MEK Kinases"@fr, "MEK Kinases"@en, "MEKK"@fr, "MEKK"@en, "MAPK-ERK Kinase Kinases"@fr, "MAPK-ERK Kinase Kinases"@en, "MEKKs"@en, "MEK Kinase"@en, "EC 2.7.11.25"@fr, "EC 2.7.11.25"@en, "MAPK-ERK Kinase Kinase"@en ; skos:altLabel "MAP3 Kinases"@fr, "MAP3 Kinases"@en, "MAP3K"@fr, "Mitogen-Activated Protein Kinase Kinase Kinase"@en, "MAPKKKs"@en, "MAPKKK"@fr, "MAPKKK"@en, "Mitogen-Activated Protein Kinase Kinase Kinases"@en, "Mitogen-Activated Protein Kinase Kinase Kinases"@fr, "MAP Kinase Kinase Kinase"@en, "Kinases, MAP Kinase Kinase"@en, "MAP3 Kinase"@en ; skos:related jvr:-X2T8VHD3-K ; owl:sameAs ; a mesh:Descriptor, skos:Concept ; dc:established "2000-01-01"^^xsd:date ; dc:created "1999-11-03"^^xsd:date ; skos:inScheme jvr: ; dc:modified "2021-04-22"^^xsd:date ; skos:broader jvr:-TP5B7P0H-F ; mesh:registryNumber "EC 2.7.11.25" ; skos:definition "Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs)."@en . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NS81BFZ3-1 skos:prefLabel "MAP Kinase Kinase Kinase 2"@fr, "MAP Kinase Kinase Kinase 2"@en ; a mesh:Descriptor, skos:Concept ; skos:broader jvr:-CS56KQ6Q-R . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .