@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-DKR4BQF0-G skos:prefLabel "RNA, Antisense"@en, "ARN antisens"@fr ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-CCP907MB-W . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-SD19LFDC-7 skos:prefLabel "Interférence par ARN"@fr, "RNA Interference"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-CCP907MB-W . jvr:-CCP907MB-W dc:established "2003-01-01"^^xsd:date ; skos:inScheme jvr: ; mesh:allowableQualifier jvr:-T2TS0S41-N, jvr:-T9HQD7ST-J, jvr:-XV06LPML-W, jvr:-D0F21513-5, jvr:-BT300B3G-Q, jvr:-N2WP45CN-V, jvr:-NFTHND7Q-8, jvr:-G30ZJ446-J, jvr:-NHL3D2X0-S, jvr:-HQRFT0C6-B, jvr:-S0CS1X5R-5, jvr:-H7K65Q8S-Z, jvr:-Q3979798-W, jvr:-CB30NGKB-3, jvr:-WZF2ZR3L-B, jvr:-R3QWLHRG-V, jvr:-NB0XHT3S-N, jvr:-FWD2BGQ0-9, jvr:-WK5F724J-1, jvr:-G7KXQWSR-5, jvr:-NKM836P1-M, jvr:-R0ZCQ8X6-J, jvr:-SBNWSM1T-R, jvr:-TJHVZCRZ-0, jvr:-Z9TSGBXH-4, jvr:-M63HSDM7-1, jvr:-L6C0XPHT-4, jvr:-W6SQV79N-S, jvr:-THHNVC7V-3 ; skos:hiddenLabel "Small Hairpin RNA"@en, "RNA, Scan"@en, "piRNA"@en, "Repeat-Associated siRNA"@en, "Petit ARNi agissant en trans"@fr, "siRNA, Repeat-Associated"@en, "scnRNA"@en, "scnRNA"@fr, "Petit ARNi associé aux répétitions"@fr, "Scan RNA"@fr, "Scan RNA"@en, "RNA, Piwi-Interacting"@en, "tasiRNA"@en, "ARN interagissant avec Piwi"@fr, "Piwi-Interacting RNA"@en, "shRNA"@en, "Short Hairpin RNA"@en, "Trans-Acting siRNA"@en, "siRNA, Trans-Acting"@en, "Petit ARN en épingle à cheveux"@fr, "Small Scan RNA"@en ; skos:broader jvr:-CWXMP0ZQ-M, jvr:-DKR4BQF0-G ; skos:related jvr:-SD19LFDC-7, jvr:-SWSBWS2L-W, jvr:-RPP5P6HF-L ; dc:modified "2010-06-25"^^xsd:date ; a mesh:Descriptor, skos:Concept ; owl:sameAs ; skos:prefLabel "RNA, Small Interfering"@en, "Petit ARN interférent"@fr ; skos:altLabel "Short Interfering RNA"@en, "Small Interfering RNA"@en, "pARNi"@fr, "Small interfering RNA"@fr, "Petit ARNi"@fr, "siRNA"@fr, "siRNA"@en ; skos:definition "Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions. siRNAs, about 26-31 nucleotides in length. They are involved in mammalian GAMETOGENESIS. siRNAs involved with GENE SILENCING of MOBILE GENETIC ELEMENTS in DROSOPHILA. siRNAs, found in TETRAHYMENA, that are homologous to internal eliminated sequences (IESs) deleted during programmed genome rearrangement. siRNA, found in plants, that are involved in silencing different gene loci than those from which they were derived."@en ; dc:created "2002-07-03"^^xsd:date . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CWXMP0ZQ-M skos:prefLabel "Petit ARN non traduit"@fr, "RNA, Small Untranslated"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-CCP907MB-W . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-RPP5P6HF-L skos:prefLabel "MicroRNAs"@en, "microARN"@fr ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-CCP907MB-W . jvr:-R0ZCQ8X6-J skos:prefLabel "agonistes (Qualificatif)"@fr, "agonists (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-SWSBWS2L-W skos:prefLabel "Complexe réprimant l'expression de l'ARN"@fr, "RNA-Induced Silencing Complex"@en ; a mesh:Descriptor, skos:Concept ; skos:related jvr:-CCP907MB-W . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .