@prefix jvr: <http://data.loterre.fr/ark:/67375/JVR> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/vocab#> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .

jvr:-BT300B3G-Q
  skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-X3XJ0X9S-5
  skos:prefLabel "Janus Kinase 1"@en, "Janus kinase 1"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-C3XKSB2M-5 .

jvr:-MRD9XRX7-7
  skos:prefLabel "TYK2 Kinase"@fr, "TYK2 Kinase"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-C3XKSB2M-5 .

jvr:-L6C0XPHT-4
  skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-XV06LPML-W
  skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WHD5Z6LX-G
  skos:prefLabel "Kinase Janus-2"@fr, "Janus Kinase 2"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-C3XKSB2M-5 .

jvr:-G7KXQWSR-5
  skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Z9TSGBXH-4
  skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-Q3979798-W
  skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-H7K65Q8S-Z
  skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-TJHVZCRZ-0
  skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-G30ZJ446-J
  skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NFTHND7Q-8
  skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-FJ7FP68S-W
  skos:prefLabel "Domaine d'homologie SRC"@fr, "src Homology Domains"@en ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-C3XKSB2M-5 .

jvr:-FWD2BGQ0-9
  skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-THHNVC7V-3
  skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJC0MZVD-R
  skos:prefLabel "Janus Kinase 3"@en, "Janus kinase 3"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:broader jvr:-C3XKSB2M-5 .

jvr:-M63HSDM7-1
  skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-S0CS1X5R-5
  skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-HQRFT0C6-B
  skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T2TS0S41-N
  skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NB0XHT3S-N
  skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-W6SQV79N-S
  skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CB30NGKB-3
  skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-K2D7SD7B-J
  skos:prefLabel "Protein-Tyrosine Kinases"@en, "Protein-tyrosine kinases"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:narrower jvr:-C3XKSB2M-5 .

jvr: a skos:ConceptScheme .
jvr:-SBNWSM1T-R
  skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-CJXMKG5Q-F
  skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-D0F21513-5
  skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-R3QWLHRG-V
  skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NHL3D2X0-S
  skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-T9HQD7ST-J
  skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ;
  a mesh:Qualifier, skos:Concept .

jvr:-N2WP45CN-V
  skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-NKM836P1-M
  skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-C3XKSB2M-5
  mesh:allowableQualifier jvr:-Q3979798-W, jvr:-THHNVC7V-3, jvr:-NB0XHT3S-N, jvr:-TJHVZCRZ-0, jvr:-CB30NGKB-3, jvr:-N2WP45CN-V, jvr:-NKM836P1-M, jvr:-WK5F724J-1, jvr:-T2TS0S41-N, jvr:-NHL3D2X0-S, jvr:-XV06LPML-W, jvr:-G30ZJ446-J, jvr:-Z9TSGBXH-4, jvr:-HQRFT0C6-B, jvr:-CJXMKG5Q-F, jvr:-FWD2BGQ0-9, jvr:-NFTHND7Q-8, jvr:-H7K65Q8S-Z, jvr:-S0CS1X5R-5, jvr:-BT300B3G-Q, jvr:-L6C0XPHT-4, jvr:-W6SQV79N-S, jvr:-G7KXQWSR-5, jvr:-T9HQD7ST-J, jvr:-SBNWSM1T-R, jvr:-D0F21513-5, jvr:-R3QWLHRG-V, jvr:-WZF2ZR3L-B, jvr:-M63HSDM7-1 ;
  dc:modified "2021-05-21"^^xsd:date ;
  skos:definition "A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains."@en ;
  skos:narrower jvr:-MRD9XRX7-7, jvr:-WHD5Z6LX-G, jvr:-X3XJ0X9S-5, jvr:-CJC0MZVD-R ;
  skos:inScheme jvr: ;
  skos:hiddenLabel "EC 2.7.10.2"@fr, "EC 2.7.10.2"@en ;
  skos:altLabel "JAK Kinases"@en, "JAK Kinases"@fr, "Kinases JAK"@fr, "Janus Kinase"@en, "Tyrosine kinases JAK"@fr, "Tyrosine-kinases JAK"@fr, "Protéines tyrosine kinases JAK"@fr ;
  a mesh:Descriptor, skos:Concept ;
  skos:related jvr:-FJ7FP68S-W ;
  dc:created "2006-07-05"^^xsd:date ;
  skos:prefLabel "Janus kinases"@fr, "Janus Kinases"@en ;
  dc:established "2007-01-01"^^xsd:date ;
  skos:broader jvr:-K2D7SD7B-J ;
  owl:sameAs <http://id.nlm.nih.gov/mesh/D053612> ;
  mesh:registryNumber "EC 2.7.10.2" .

jvr:-WK5F724J-1
  skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .

jvr:-WZF2ZR3L-B
  skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ;
  a mesh:Qualifier, skos:Concept .